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Dietary Intervention in Cognitive Aging


This study will test two dietary interventions in overweight, middle-aged adults with subjective memory complaints: a powdered berry supplement and a carbohydrate-restricted diet designed to induce ketone metabolism.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 65 Years All No
January 2016
July 2023

  • Overweight
  • Subjective memory complaints

  • Diabetes
  • Liver or kidney disease
  • Age-related memory disorder
  • Neurologic or psychiatric condition
  • Substance abuse

Subjective memory complaints may be an early indicator of future dementia. In this study, two dietary interventions (a powdered berry supplement and a carbohydrate-restricted diet designed to induce ketone metabolism) will be compared to placebo (inactive substance) to determine if they can improve memory and enhance metabolic function and related factors in individuals with such complaints.

Deposition of amyloid-beta in the brain is the earliest recognized biomarker of Alzheimer's disease. Demographically, amyloid-beta accumulation begins to accelerate at age 50, when the incidence of metabolic disturbance increases as well. Elevated insulin levels, a type of metabolic disturbance, have been associated with Alzheimer's. Investigators will assess how the interventions affect insulin resistance and cognitive function.

The ultimate goal is to develop interventions that might forestall or prevent progression of neurocognitive decline in at-risk individuals.

Name City State Zip Status Primary Contact
Dept of Psychiatry & Behavioral Neuroscience, UC Academic Health Center
Cincinnati Ohio 45267-0559 Recruiting Marcelle Shidler, MA

University of Cincinnati

Name Role Affiliation
Robert Krikorian, PhD Principal Investigator University of Cincinnati

Name Phone Email
Marcelle Shidler 513-558-2455


Early Intervention in Cognitive Aging