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Diet and Cognitive Training for Mild Cognitive Impairment


The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet incorporates the DASH (Dietary Approaches to Stop Hypertension) diet, which has been shown to lower high blood pressure, a risk factor for Alzheimer's disease. This study will test the whether the diet combined with Brain HQ cognitive brain training exercises improves cognitive performance in older adults.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years N/A All Yes
February 11, 2019
May 31, 2022

  • High school education
  • English speaking
  • Resident of Marion County, Indiana
  • Natural-born U.S. citizen

  • Living in a nursing home
  • Diagnosis of dementia, Alzheimer's disease, cancer with short life expectancy, multiple sclerosis, epilepsy, schizophrenia, bipolar disorder, Parkinson's disease; current chemotherapy or radiation therapy; history of brain tumor, brain surgery, or brain infection; stroke or myocardial infarction within the past 12 months
  • Current alcohol consumption of eight drinks per week for women or 15 drinks per week for men
  • Poor vision or color blind
  • Inability to communicate clearly that could interfere with the study, as determined by the study contact
  • Unable or unwilling to provide blood sample at the start of the study
  • Tumor, hemorrhage, aneurysm, hydrocephalus, or other significant clinical finding from the brain MRI test at the start of the study

The MIND diet is based on the Mediterranean diet, which some studies have shown is associated with a lower risk for dementia. BrainHQ is an online program of cognitive exercises based on neuroplasticity the brain's natural ability to change. This study will look at the effects of combining the MIND diet and BrainHQ cognition exercises on cognition.

Participants will complete a cognitive assessment at the start of the study and then be randomized to one of four study groups: 1) MIND foods and cognitive training, 2) MIND foods and control training, 3) control foods and cognitive training, or 4) control foods and control training.

All interventions will be conducted through applications (apps) running on a tablet computer device that will be provided to all participants for the length of study. Participants will select foods using an online shopping format on the provided tablet device. Selected foods will be prepared and delivered to each participant by the study team for 12 weeks. After the 12 weeks, free food deliveries will stop but participants in the cognitive training group will continue to have access to the BrainHQ cognitive test. Those participants in the MIND food study groups will be encouraged to maintain MIND food choices.

Name City State Zip Status Primary Contact
Regenstrief Institute
Indianapolis Indiana 46202 Recruiting Lyndsi Moser, BA, CCRP

Indiana University

  • National Institutes of Health (NIH)

Name Phone Email
Daniel Clark, PhD 317 274 9292
Denisha Y Ferguson, MBA 317 274 9082


MINDSpeed Food and Brain Training RCT