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Comparative Research of Alzheimer's Disease Drug (COMET-AD)

  • Terminated

This study will compare the effectiveness of approved medications for treating Alzheimer's disease in participants from real-world memory care clinics in Indiana.

 

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A Both No
April 2011
September 2014
300

++Diagnosis of possible or probable Alzheimer's disease++Planning to initiate treatment with a cholinesterase inhibitor (donepezil, galantamine, or rivastigmine)++Planning to continue care at one of the study sites++Family caregiver willing to complete study outcome assessments++Access to a telephone++Ability to understand English-language survey instruments

++Prior serious adverse event from the study medications

The goal of this study is to improve the nation's capacity to conduct comparative effectiveness research (CER), which compares the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in real-world settings. The Regenstrief Institute will collaborate with Indiana University's Center for Aging Research and Division of Clinical Pharmacology to compare the effectiveness of approved medications for treating Alzheimer's disease in participants from five memory care clinics in central Indiana. These drugs are donepezil, galantamine, and rivastigmine. Investigators will analyze treatment patterns and patients' clinical outcomes. 

 

Name City State Zip Status Primary Contact
Touchpoint Fishers Indiana 46037

Methodist Center for Geriatric Medicine Indianapolis Indiana 46202

University Clinical Neurology Indianapolis Indiana 46202

Wishard Health Services Indianapolis Indiana 46202

St. Vincent Center for Healthy Aging Indianapolis Indiana 46260

Regenstrief Institute, Indiana University Center for Aging Research

  • Agency for Healthcare Research and Quality (AHRQ) - U.S. Fed

Name Role Affiliation
Malaz Boustani, MD, MPH Principal Investigator Regenstrief Institute, Indiana University Center for Aging Research

Name Phone Extension Email
Amie Frame, MPH 317-423-5910 amiframe@iupui.edu

Comparative Effectiveness Research Trial of Alzheimer`s Disease Drug