Comparative Research of Alzheimer's Disease Drug (COMET-AD)
This study will compare the effectiveness of approved medications for treating Alzheimer's disease in participants from real-world memory care clinics in Indiana.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
++Diagnosis of possible or probable Alzheimer's disease++Planning to initiate treatment with a cholinesterase inhibitor (donepezil, galantamine, or rivastigmine)++Planning to continue care at one of the study sites++Family caregiver willing to complete study outcome assessments++Access to a telephone++Ability to understand English-language survey instruments
++Prior serious adverse event from the study medications
The goal of this study is to improve the nation's capacity to conduct comparative effectiveness research (CER), which compares the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in real-world settings. The Regenstrief Institute will collaborate with Indiana University's Center for Aging Research and Division of Clinical Pharmacology to compare the effectiveness of approved medications for treating Alzheimer's disease in participants from five memory care clinics in central Indiana. These drugs are donepezil, galantamine, and rivastigmine. Investigators will analyze treatment patterns and patients' clinical outcomes.
Methodist Center for Geriatric Medicine
University Clinical Neurology
Wishard Health Services
St. Vincent Center for Healthy Aging
Regenstrief Institute, Indiana University Center for Aging Research
- Agency for Healthcare Research and Quality (AHRQ)
|Malaz Boustani, MD, MPH||Principal Investigator||Regenstrief Institute, Indiana University Center for Aging Research|
|Amie Frame, MPHfirstname.lastname@example.org|
Comparative Effectiveness Research Trial of Alzheimer's Disease Drug
- Callahan CM, Boustani MA, Unverzagt FW, Austrom MG, Damush TM, Perkins AJ, Fultz BA, Hui SL, Counsell SR, Hendrie HC. Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: a randomized controlled trial. JAMA. 2006 May 10;295(18):2148-57.
- Boustani M, Callahan CM, Unverzagt FW, Austrom MG, Perkins AJ, Fultz BA, Hui SL, Hendrie HC. Implementing a screening and diagnosis program for dementia in primary care. J Gen Intern Med. 2005 Jul;20(7):572-7.