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Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Active, not recruiting

This study examines the impact on older adults of learning the results of amyloid brain imaging, which can indicate risk for Alzheimer's disease. 

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years 80 Years All Yes
November 2016
December 2020

  • At least one first-degree relative (parent, sibling, child) with Alzheimer's disease
  • Study partner who will complete surveys and interviews and accompany subject to visits
  • Willingness to give a cheek swab for Alzheimer's-related genetic testing
  • English speaking

  • History of stroke or head trauma
  • Active medical or psychiatric illness that is unstable or progressive
  • Taking memantine

The REVEAL-SCAN clinical trial examines the psychological and behavioral impact of learning the results of amyloid brain imaging, which indicates the risk of developing Alzheimer's by age 85. The study's goal is to learn how to communicate these brain-scan results and the risk of developing Alzheimer's dementia in a diverse population of cognitively normal older adults.

Investigators will use genetic tests to ensure that roughly half of participants have elevated amyloid levels and half do not. All participants will receive an Alzheimer's risk assessment. Half of them will learn their amyloid brain-scan results during the assessment; the other half will learn their results 6 months later. Cognitive, psychological, and behavioral outcomes will be compared between the two groups. Participants will be followed for up to 9 months, with up to seven in-person visits and five phone calls.

Name City State Zip Status Primary Contact
Brigham and Women's Hospital
Boston Massachusetts 02115

University of Michigan
Ann Arbor Michigan 48109

Duke University
Durham North Carolina 27705

University of Pennsylvania
Philadelphia Pennsylvania 19104

Brigham and Women's Hospital

  • University of Pennsylvania
  • University of Michigan
  • Duke University
  • Boston University
  • National Institute on Aging (NIA)

Name Role Affiliation
Robert C. Green, MD, MPH Principal Investigator Brigham and Women's Hospital
Jason Karlawish, MD Principal Investigator University of Pennsylvania
J. Scott Roberts, PhD Principal Investigator University of Michigan
Kathleen Welsh-Boomer, PhD Principal Investigator Duke University

Name Phone Email
Alexandra Hempel, BA 617-264-5876


Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)