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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment


This study will evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss.

Minimum Age Maximum Age Gender Healthy Volunteers
55 Years 95 Years All No
November 29, 2017
July 31, 2022

  • Memory or other cognitive complaints
  • Cognitive impairment as measured by the Wechsler Memory Scale III Logical Memory test
  • Mini-Mental State Examination score of 23 or more
  • Individual who can serve as a study informant (can be via telephone)
  • Access to a home computer and acceptable Internet speed for study duration
  • English speaking

  • Diagnosis of dementia
  • Schizophrenia, schizoaffective disorder, major depression, psychosis, or bipolar I disorder
  • Active suicidal ideation or plan
  • Alcohol or substance use disorder in past 6 months
  • Clinical stroke with residual neurological deficits
  • Prohibited medications: benzodiazepines in lorazepam equivalents of 1 mg or more daily, narcotics, and anticholinergics
  • Central nervous system infection, with cerebrospinal fluid evidence of meningitis, encephalitis, or other infectious process
  • Dementia of any type, Huntington's disease, multiple sclerosis, Parkinson's disease, other neurological disorders with focal signs (e.g., amyotrophic lateral sclerosis). and mental retardation
  • Severe unstable medical illness (successfully treated cancer is not exclusionary)
  • Inability to undergo magnetic resonance imagine scan, including pacemaker and metal implants
  • Online brain training or crossword puzzle use 2 or more times per week in past year (must also refrain from these activities during the study)
  • Participation in another intervention trial for cognitive impairment

In this 18-month study, participants will be randomly assigned to computer-based cognitive training or to crossword puzzle training that can be completed at home. Participants will be asked to visit the memory clinic for screening and follow-up visits to assess changes in memory and cognitive function.

Name City State Zip Status Primary Contact
New York State Psychiatric Institute
New York New York 10032 Recruiting Jessica L D'Antonio, B.A
Duke University
Durham North Carolina 27710 Recruiting Caroline Hellegers, MA

New York State Psychiatric Institute

  • Duke University
  • Queens College, The City University of New York

Name Role Affiliation
Davangere P Devanand, MD Principal Investigator Columbia University
Murali Doraiswamy, MD Principal Investigator Duke University
Joel Sneed, PhD Principal Investigator Queens College

Name Phone Email
Jessica L D'Antonio, BA 646-774-8674
Laura Simon-Pearson, BA 646-774-8671


Cognitive Training and Neuroplasticity in Mild Cognitive Impairment