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Clinical Evaluation of Florbetapir F 18 (18F-AV-45)


This study is designed to standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden in subjects participating in other studies, such as longitudinal studies of aging and studies of biomarkers for neurodegenerative diseases.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A Both Yes
December 2009
December 2017

++At least 18 years of age++Ability to tolerate the PET scan procedures

++Clinically significant hepatic, renal, pulmonary, metabolic, or endocrine conditions++Clinically significant cardiovascular disease, such as cardiac surgery or myocardial infarction within the last 4 weeks, unstable angina, significant cardiac arrhythmia or conduction disturbance, uncontrolled high blood pressure++History of drug or alcohol abuse within the last year or prior prolonged history of abuse++Women of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception; women of childbearing potential must not be pregnant or breastfeeding++History of relevant severe drug allergy or hypersensitivity, as determined by investigators++Taking of an investigational medication under an FDA IND protocol within the last 30 days++Unstable medical comorbidities that pose a potential safety risk to the subject++Radiopharmaceutical for imaging or therapy within the past 24 hours prior to the imaging session for this study unless the trial sponsor has approved it


For more information about individual study sites, contact Avid Clinical Operations at 1-215-298-0700 or

Name City State Zip Status Primary Contact
Banner Health
Phoenix Arizona 85006

Banner Sun Health Research Institute
Sun City Arizona 85351

UC Davis
Davis California 95618

UC Irvine
Irvine California 92697

University of Southern California
Los Angeles California 90033

UC Irvine
Orange California 92868

UC San Francisco
San Francisco California 94121

UC San Francisco Memory Center
San Francisco California 94143

Mayo Clinic Jacksonville
Jacksonville Florida 32254

Mt. Sinai Medical Center
Miami Beach Florida 33140

Northwestern University
Chicago Illinois 60611

University of Kansas
Kansas City Kansas 66160

Johns Hopkins University
Baltimore Maryland 21287

Massachusetts General Hospital
Boston Massachusetts 02114

University of Mississippi Medical Center
Jackson Mississippi 39216

Washington University School of Medicine
Saint Louis Missouri 63110

Duke University
Durham North Carolina 27710

Wake Forest University
Winston-Salem North Carolina 27104

Philadelphia Pennsylvania 19107

University of Pennsylvania
Philadelphia Pennsylvania 19107

Butler Hospital
Providence Rhode Island 02906

University of Tennessee
Knoxville Tennessee 37920

Nashville Tennessee 37232

Dallas Texas 75231

Dallas Texas 75235

Dallas Texas 75390

Avid Radiopharmaceuticals

Name Role Affiliation
Chief Medical Officer Study Director Avid Radiopharmaceuticals

Name Phone Email
Avid Clinical Operations 215-298-0700


Clinical Evaluation of Florbetapir F 18 (18F-AV-45)