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Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

  • Completed

This study is designed to standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden in subjects participating in other studies, such as longitudinal studies of aging and studies of biomarkers for neurodegenerative diseases.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A Both Yes
December 2009
December 2017
600

++At least 18 years of age++Ability to tolerate the PET scan procedures

++Clinically significant hepatic, renal, pulmonary, metabolic, or endocrine conditions++Clinically significant cardiovascular disease, such as cardiac surgery or myocardial infarction within the last 4 weeks, unstable angina, significant cardiac arrhythmia or conduction disturbance, uncontrolled high blood pressure++History of drug or alcohol abuse within the last year or prior prolonged history of abuse++Women of childbearing potential who are not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception; women of childbearing potential must not be pregnant or breastfeeding++History of relevant severe drug allergy or hypersensitivity, as determined by investigators++Taking of an investigational medication under an FDA IND protocol within the last 30 days++Unstable medical comorbidities that pose a potential safety risk to the subject++Radiopharmaceutical for imaging or therapy within the past 24 hours prior to the imaging session for this study unless the trial sponsor has approved it

None

For more information about individual study sites, contact Avid Clinical Operations at 1-215-298-0700 or clinicaloperations@avidrp.com.

Name City State Zip Status Primary Contact
Banner Health Phoenix Arizona 85006

Banner Sun Health Research Institute Sun City Arizona 85351

UC Davis Davis California 95618

UC Irvine Irvine California 92697

University of Southern California Los Angeles California 90033

UC Irvine Orange California 92868

UC San Francisco San Francisco California 94121

UC San Francisco Memory Center San Francisco California 94143

Mayo Clinic Jacksonville Jacksonville Florida 32254

Mt. Sinai Medical Center Miami Beach Florida 33140

Northwestern University Chicago Illinois 60611

University of Kansas Kansas City Kansas 66160

Johns Hopkins University Baltimore Maryland 21287

Massachusetts General Hospital Boston Massachusetts 02114

University of Mississippi Medical Center Jackson Mississippi 39216

Washington University School of Medicine Saint Louis Missouri 63110

Duke University Durham North Carolina 27710

Wake Forest University Winston-Salem North Carolina 27104

Jefferson Philadelphia Pennsylvania 19107

University of Pennsylvania Philadelphia Pennsylvania 19107

Butler Hospital Providence Rhode Island 02906

University of Tennessee Knoxville Tennessee 37920

Vanderbilt Nashville Tennessee 37232

UTSW Dallas Texas 75231

UTSW Dallas Texas 75235

UTSW Dallas Texas 75390

Avid Radiopharmaceuticals

Name Role Affiliation
Chief Medical Officer Study Director Avid Radiopharmaceuticals

Name Phone Extension Email
Avid Clinical Operations 215-298-0700 clinicaloperations@avidrp.com

Clinical Evaluation of Florbetapir F 18 (18F-AV-45)