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Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Recruiting

Disruption of the blood-brain barrier, which is important for protecting the brain, could be an early process that precedes Alzheimer's disease. This study will test a method for measuring disruptions to the blood-brain barrier using advanced magnetic resonance imaging (MRI) methods in cognitively normal younger and older adults and adults with mild cognitive impairment (MCI), a condition that puts people at higher risk for Alzheimer's.

Minimum Age Maximum Age Gender Healthy Volunteers
20 Years 85 Years All Yes
December 18, 2018
February 2021
60

  • Diagnosed with amnestic MCI

  • Pregnant, planning to get pregnant, or nursing
  • Claustrophobia
  • Heart pacemaker
  • Intracranial clips, metal implants, unremovable jewelry, metal in eyes
  • History or presence of any other major medical, neurologic, or psychiatric conditions, such as Alzheimer's, Parkinson's, or stroke
  • Kidney or liver disease as this may cause concerns related to the contrast agent
  • Allergy to the MRI contrast agent gadolinium

Microvascular changes related to disruption of the blood brain barrier can be measured using permeability surface area. Participants will undergo an MRI brain scan for up to 60 minutes that employs an imaging technique called GRASP DCE-MRI (golden-angle radial sparse parallel dynamic contrast agent-enhanced MRI). Researchers will compare the patterns of permeability surface area in normal versus abnormal aging.

Name City State Zip Status Primary Contact
New York University School of Medicine
New York New York 10016 Recruiting Fatemeh Adlparvar
212-263-7744
Fatemeh.Adlparvar@nyumc.org

NYU Langone Health

Name Role Affiliation
Yulin Ge, MD Principal Investigator NYU Langone Health

Name Phone Email
Fatemeh Adlparvar 212 263 0380 Fatemeh.Adlparvar@nyumc.org

NCT03389698

Developing Advanced Blood-Brain Barrier Permeability Imaging for Early Alzheimer's Disease