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Augmenting Cognitive Training in Older Adults (ACT)

Recruiting

This study will investigate the effects of combined cognitive training and transcranial direct current stimulation (tDCS) on cognition and brain function in older adults.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years 89 Years All Yes
August 8, 2017
August 2022
1116

  • Evidence of age-related cognitive decline, as determined by assessment

  • Neurological disorders (e.g., dementia, stroke, seizures, traumatic brain injury)
  • Evidence of cognitive impairment
  • Past opportunistic brain infection
  • Major psychiatric illness, such as schizophrenia, intractable affective disorder, current substance dependence diagnosis, or severe major depression and/or suicidality
  • Unstable and chronic medical conditions, such as cancer (other than basal cell skin) and severe diabetes
  • Inability to undergo magnetic resonance imaging (e.g., claustrophobia, metal implants)
  • Physical impairment that would interfere with motor response or lying still for 1 hour
  • Inability to walk two blocks without stopping
  • Currently on GABA-ergic or glutamatergic medications, or on sodium channel blockers
  • Left-handedness

tDCS is a noninvasive procedure that uses electrodes to stimulate brain regions involved in cognitive function. In this study, investigators are testing whether tDCS could enhance neural plasticity when paired with a training task.

Participants will be assigned to either cognitive training, using the online Posit Science BrainHQ system, or educational training, consisting of educational videos produced by the National Geographic Channel. During the training task, participants will undergo either active stimulation for 20 minutes or sham stimulation. Researchers will compare changes in cognition and brain function through neurocognitive, clinical, and neuroimaging assessments.

For more information about the study or study sites, contact Adam Woods via email or phone: 352-294-5842.

Name City State Zip Status Primary Contact
University of Arizona
Tucson Arizona 85721 Recruiting

Village of Gainesville
Gainesville Florida 32606 Recruiting

University of Florida McKnight Brain Institute
Gainesville Florida 32610 Recruiting

University of Florida

  • University of Arizona
  • National Institute on Aging (NIA)

Name Role Affiliation
Adam Woods, Ph.D Principal Investigator University of Florida

Name Phone Email
Adam Woods, Ph.D. 352-294-5842 ajwoods@ufl.edu

NCT02851511

Augmenting Cognitive Training In Older Adults