Alzheimer's Disease Education and Referral Center

Aspirin in Reducing Events in the Elderly (ASPREE)

Aspirin in Reducing Events in the Elderly (ASPREE)

Overall Status: 
Active, not recruiting
Brief Description: 

The ASPREE study will examine whether the potential benefits of low-dose aspirin (particularly preventing heart disease, stroke, certain cancers, and dementia) outweigh the risks (particularly bleeding) in people over age 70. ASPREE will determine whether taking a daily low-dose aspirin will extend the length of a disability-free life in healthy participants aged 70 years and above.

Patient Qualifications: 
Min AgeGenderHealthy Volunteers
70 Years
Both
Accepts Healthy Volunteers
Inclusion Criteria: 

  • Men and women 70 years of age and over

Exclusion Criteria: 

  • History of a diagnosed cardiovascular event
  • Serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease
  • Current or recurrent condition with a high risk of major bleeding, for example, cerebral aneurysm
  • Anemia
  • Current participation in a clinical trial
  • Systolic blood pressure of ≥180 mmHg and/or diastolic blood pressure of ≥105 mmHg
  • History of dementia
  • Severe difficulty or inability to perform any one of the 6 Katz activities of daily living
  • Noncompliance to taking pill
  • Absolute contraindication or allergy to aspirin
  • Current continuous use of aspirin or other antiplatelet drug or anticoagulant for secondary prevention; people with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low-dose aspirin or placebo

Detailed Description: 

Low-dose aspirin therapy has been shown to reduce the risk of vascular events, largely in middle-aged people. There is also some evidence of its potential to reduce the rate of intellectual decline and certain types cancers in older participants. However, these benefits may be offset by adverse effects, such as potential bleeding. The balance of risks and benefits of low-dose aspirin has not been established in older persons. Previous studies on the effects of aspirin in primary prevention have mainly focused on cardiovascular outcomes. In the elderly, these outcomes alone may not be the most appropriate measure of benefit associated with aspirin treatment. Prolonging a life free of functional disability in a healthy aging population would be the most desirable benefit of aspirin as a preventive medicine.

Central Contact Information: 

If you are interested in joining ASPREE, please contact a location near you from the list below. For more information about this trial, visit the ASPREE website.

Locations: 
Map Marker CityStateZip CodePrimary Contact

Geolocation is 33.5075555, -86.8093239

The University of Alabama at Birmingham
Birmingham
Alabama
35294

Geolocation is 37.4457966, -122.1575745

Palo Alto Medical Foundation Research Institute
Palo Alto
California
94301

Geolocation is 38.9178427, -77.0218255

Howard University
Washington
District of Columbia
20060

Geolocation is 29.6130239, -82.371937

University of Florida Department of Aging and Geriatrics
Gainsville
Florida
32611

Geolocation is 33.7321902, -84.4225186

Morehouse School of Medicine
Atlanta
Georgia
30310

Geolocation is 33.7980995, -84.3259367

Emory/ Atlanta VAMC
Atlanta
Georgia
30322

Geolocation is 33.474324, -81.9899547

Georgia Health Sciences University
Augusta
Georgia
30912

Geolocation is 41.8816606, -87.6926257

Rush Alzheimer's Disease Center
Chicago
Illinois
60612

Geolocation is 41.659363, -91.5487099

University of Iowa
Iowa City
Iowa
52242

Geolocation is 39.0704366, -94.6967189

Kansas University Medical Center
Kansas City
Kansas
66106

Geolocation is 30.4483779, -91.188708

Baton Rouge General
Baton Rouge
Louisiana
70801

Geolocation is 30.4192451, -91.1448981

Pennington Biomedical Research Center
Baton Rouge
Louisiana
70808

Geolocation is 30.3911214, -91.0634024

Mary Bird Perkins Our Lady of the Lake Cancer Center
Baton Rouge
Louisiana
70809

Geolocation is 30.4754702, -90.1009108

Mary Bird Perkins St. Tammany Parish Hospital
Covington
Louisiana
70433

Geolocation is 29.5957696, -90.7195348

Mary Bird Perkins Terrebonne General Hospital
Houma
Louisiana
70360

Geolocation is 29.9595769, -90.0770127

LSU Health Sciences- New Orleans
New Orleans
Louisiana
70112

Geolocation is 29.9595769, -90.0770127

Tulane Medical Center
New Orleans
Louisiana
70112

Geolocation is 32.49, -93.77

LSU Health Sciences- Shreveport
Shreveport
Louisiana
71130

Geolocation is 42.3053253, -83.6694169

University of Michigan
Ann Arbor
Michigan
48109

Geolocation is 42.348495, -83.0602998

Wayne State University
Detroit
Michigan
48201

Geolocation is 42.3664506, -83.0737195

Henry Ford Health System
Detroit
Michigan
48202

Geolocation is 42.5123116, -83.4750241

Detroit Clinical Research Center
Novi
Michigan
48377

Geolocation is 44.851048, -93.2395012

Health Partners Research Foundation
Minneapolis
Minnesota
55425

Geolocation is 44.9687549, -93.0485951

Phalen Village Clinic
St. Paul
Minnesota
55106

Geolocation is 40.6517521, -74.2149978

Central Jersey Medical Center
Elizabeth
New Jersey
07202

Geolocation is 40.7383636, -74.197388

New Jersey Medical College
Newark
New Jersey
07103

Geolocation is 40.7492678, -73.6406845

Winthrop University Hospital
Mineola
New York
11501

Geolocation is 36.1046869, -79.8128649

Wake Forest University Baptist Medical Center
Greensboro
North Carolina
27408

Geolocation is 35.612661, -77.3663538

The Brody School of Medicine at ECU
Greenville
North Carolina
27834

Geolocation is 40.0397682, -75.145782

Albert Einstein Medical Center
Philadelphia
Pennsylvania
19141

Geolocation is 40.4424402, -79.9531948

University of Pittsburgh Health Sciences Research Center
Pittsburgh
Pennsylvania
15260

Geolocation is 41.8684902, -71.3883751

Memorial Hospital of Rhode Island
Pawtucket
Rhode Island
02860

Geolocation is 35.1516237, -90.0349866

University of Tennessee Health Science Center
Memphis
Tennessee
38105

Geolocation is 32.8113367, -96.8397899

University of Texas Southwestern Medical Center at Dallas
Dallas
Texas
75390

Geolocation is 29.3106102, -94.7772493

University of TX Medical Branch
Galveston
Texas
77555

Geolocation is 26.1906306, -97.6961026

Regional Academic Health Center
Harlingen
Texas
78550

Geolocation is 29.5060908, -98.577596

UT Health Science Center at San Antonio
San Antonio
Texas
78229
Lead Sponsor: 
Agency
Minneapolis Medical Research Foundation
Collaborator Sponsor: 
Agency
National Health and Medical Research Council, Australia
Bayer
Monash University
Berman Center for Outcomes and Clinical Research
Facility Investigators: 
NameRoleAffiliation
Richard Grimm, MD, PhD
Principal Investigator
Berman Center for Outcomes and Clinical Research
John McNeil, MD
Principal Investigator
Monash University
Study Contact: 
NamePhoneEmail
Nathan J. Tessum
612-341-7907
Brenda Kirpach
612-341-7922
Locations
 
 
ClinicalTrials.gov ID 
NCT01038583 (follow link to view full record on ct.gov in new window)
Official Title: 
Aspirin in Reducing Events in the Elderly
Study Start Date: 
January 2010
Study End Date: 
August 2016
Enrollment: 
19000