APOE, Metabolism, and Cognitive Function
This study aims to better understand the relationship between variations of the APOE gene and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults. Results may help investigators identify new targets for the prevention and treatment of cognitive decline and dementia.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|18 Years||65 Years||All||Yes|
- Cognitively normal
- Good health
- Pregnant or breastfeeding
- Current bleeding disorder
- History of stroke, seizures, Parkinson's disease, head injury with loss of consciousness, or other dementing disorder
- History of alcoholism or drug abuse
- History of schizophrenia or current bipolar disorder or major depression
- Vision or hearing loss that could interfere with cognitive testing
Impaired metabolism and APOE genotype are independent risk factors for cognitive impairment and dementia. In this study researchers will test whether the different versions of APOE have varying effects on whole body and brain metabolism.
Researchers will measure participants' metabolic rates while resting and during a computer-based cognitive challenge using a technique called indirect calorimetry that measures oxygen intake and carbon dioxide output through a loose-fitting face mask. Participants will also be asked to provide blood samples for genetic testing of APOE genotype and two urine samples to measure carbohydrates, fats, and proteins the body is metabolizing.
University of Kentucky Medical Center
Lance Johnson, PhD
|Lance Johnson, PhD||Principal Investigator||University of Kentucky|
|Lance Johnson, PhD||859-323-2146||Johnson.Lance@uky.edu|
APOE, Metabolism and Cognitive Function: An Assessment Via Indirect Calorimetry