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APOE, Metabolism, and Cognitive Function


This study aims to better understand the relationship between variations of the APOE gene and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults. Results may help investigators identify new targets for the prevention and treatment of cognitive decline and dementia.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years 65 Years All Yes
April 24, 2018
April 30, 2020

  • Cognitively normal
  • Good health

  • Pregnant or breastfeeding
  • Current bleeding disorder
  • History of stroke, seizures, Parkinson's disease, head injury with loss of consciousness, or other dementing disorder
  • History of alcoholism or drug abuse
  • History of schizophrenia or current bipolar disorder or major depression
  • Vision or hearing loss that could interfere with cognitive testing

Impaired metabolism and APOE genotype are independent risk factors for cognitive impairment and dementia. In this study researchers will test whether the different versions of APOE have varying effects on whole body and brain metabolism.

Researchers will measure participants' metabolic rates while resting and during a computer-based cognitive challenge using a technique called indirect calorimetry that measures oxygen intake and carbon dioxide output through a loose-fitting face mask. Participants will also be asked to provide blood samples for genetic testing of APOE genotype and two urine samples to measure carbohydrates, fats, and proteins the body is metabolizing.

Name City State Zip Status Primary Contact
University of Kentucky Medical Center
Lexington Kentucky 40536 Recruiting Lance Johnson, PhD

Lance Johnson

Name Role Affiliation
Lance Johnson, PhD Principal Investigator University of Kentucky

Name Phone Email
Lance Johnson, PhD 859-323-2146


APOE, Metabolism and Cognitive Function: An Assessment Via Indirect Calorimetry