Skip to main content

Alzheimer's Prevention Through Exercise


The purpose of this study is to learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A Both No
November 2013
April 2019

  • Clinical Dementia Rating score of 0 (nondemented)
  • Brain scan (florbetapir PET) evidence of cerebral amyloidosis
  • Sedentary or underactive, as determined by the Telephone Assessment of Physical Activity
  • If taking medications, on stable doses for at least 30 days
  • Ability to complete the 1-year exercise intervention

  • Clinically significant major psychiatric disorder, such as major depression, or psychiatric symptoms that could impair completion of the study
  • Clinically significant systemic illness that may affect safety or completion of the study
  • History of clinically evident stroke
  • Clinically significant infection within the last 30 days
  • Active cardiac condition (such as angina, myocardial infarction, atrial fibrillation) or pulmonary condition within the past 2 years that could pose a safety risk to the participant, unless cleared for exercise by the participant's primary care physician or cardiologist
  • Uncontrolled hypertension within the last 6 months
  • History of drug or alcohol abuse within the last 2 years
  • Insulin-dependent diabetes mellitus
  • Significant pain or musculoskeletal disorder prohibiting participation in an exercise program
  • Unwillingness to undergo or contraindication to brain MRI scan
  • History within the last 5 years of cancer or primary/recurrent malignant disease, with the exception of resected localized cutaneous squamous cell carcinoma, nonmetastatic basal cell carcinoma, cervical carcinoma, or prostate cancer

The main purpose of this study is to learn about the possible benefits of aerobic exercise in controlling or reducing the amount of amyloid in the brain of older adults at risk of developing Alzheimer's disease. Amyloid is a protein whose abnormal deposits in the brain are a hallmark of the disease. Investigators will also assess whether exercise reduces changes in brain structure that may lead to Alzheimer's and increases cognitive ability.

Participants in the intervention group will engage in aerobic exercise for 150 minutes per week (over 3 to 5 days) for 1 year. Those in the control group will be given educational materials on starting an exercise program but will receive no formal support for their exercise program.

Name City State Zip Status Primary Contact
University of Kansas Medical Center
Kansas City Kansas 66160 Recruiting Angela Van Sciver

University of Kansas

  • National Institute on Aging (NIA)

Name Role Affiliation
Jeffrey Burns, MD Principal Investigator University of Kansas

Name Phone Email
Angela Van Sciver 913-945-5029


Effect of Aerobic Exercise on Pathophysiology of PreClinical Alzheimer's Disease