Start:
November 2013
End:
December 2019
Enrollment:
100
What Is This Study About?
The purpose of this study is to learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.
Do I Qualify To Participate in This Study?
Must have:
- Clinical Dementia Rating score of 0 (nondemented)
- Brain scan (florbetapir PET) evidence of cerebral amyloidosis
- Sedentary or underactive, as determined by the Telephone Assessment of Physical Activity
- If taking medications, on stable doses for at least 30 days
- Ability to complete the 1-year exercise intervention
Must NOT have:
- Clinically significant major psychiatric disorder, such as major depression, or psychiatric symptoms that could impair completion of the study
- Clinically significant systemic illness that may affect safety or completion of the study
- History of clinically evident stroke
- Clinically significant infection within the last 30 days
- Active cardiac condition (such as angina, myocardial infarction, atrial fibrillation) or pulmonary condition within the past 2 years that could pose a safety risk to the participant, unless cleared for exercise by the participant's primary care physician or cardiologist
- Uncontrolled hypertension within the last 6 months
- History of drug or alcohol abuse within the last 2 years
- Insulin-dependent diabetes mellitus
- Significant pain or musculoskeletal disorder prohibiting participation in an exercise program
- Unwillingness to undergo or contraindication to brain MRI scan
- History within the last 5 years of cancer or primary/recurrent malignant disease, with the exception of resected localized cutaneous squamous cell carcinoma, nonmetastatic basal cell carcinoma, cervical carcinoma, or prostate cancer
Need Help?
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at
800-438-4380
or
email ADEAR.
Where Is This Study Located?
Collaborator Sponsor
-
National Institute on Aging (NIA)
Source:
ClinicalTrials.gov ID:
NCT02000583