Alzheimer's Disease Multiple Intervention Trial
The purpose of this study is to conduct a 2-year, randomized, controlled clinical trial to improve functioning among older adults with Alzheimer's disease. The trial will compare a control group receiving best practices primary care with an intervention group receiving best practices primary care plus a home-based occupational therapy intervention.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
++Current patient at Wishard Health Services in central Indiana++Diagnosis of possible or probable Alzheimer's disease++Age 45 or older++English speaking++Hearing adequate to answer questions in person or by telephone++Community-dwelling (includes senior communities but not skilled nursing facilities)++Caregiver willing to participate in the study++Willing to receive home visits++Live in Indianapolis metro area and are planning to continue care at a primary care clinic
++Age 18 or older++English speaking++Hearing adequate to answer questions in person or by telephone++Community-dwelling++Willing to receive home visits
++Not a current patient at Wishard Health Services++Non-English speaking++Currently enrolled in another study++Non-community dwelling or residing in a skilled nursing facility
The current study will test a home-based intervention designed to slow the rate of functional decline among older adults with Alzheimer's disease. A previous clinical trial demonstrated the effectiveness of collaborative primary care for older adults with Alzheimer's. In the prior trial, guideline-level medical care resulted in improved quality of care and improved behavioral and psychological symptoms over 1 year among patients and their caregivers. Despite significant differences among study groups on neuropsychiatric test scores, no significant difference in functional decline was found between groups. Both study groups experienced a significant decline in function over 18 months.
This study also builds on recently reported research that demonstrated the short-term efficacy of home-based occupational therapy among older adults with dementia. These trials showed that older adults with dementia, including Alzheimer's disease, can both participate in and benefit from occupational therapy-based interventions delivered in the home.
|Wishard Health Services||Indianapolis||Indiana||46202||
- National Institute on Aging (NIA) - NIH
|Christopher M Callahan, MD||Principal Investigator||Indiana University School of Medicine|
|Carrie S. Morris, MS, OTRfirstname.lastname@example.org|
- Callahan CM, Boustani MA, Unverzagt FW, Austrom MG, Damush TM, Perkins AJ, Fultz BA, Hui SL, Counsell SR, Hendrie HC. Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: a randomized controlled trial. JAMA. 2006 May 10;295(18):2148-57.
- Callahan CM, Boustani M, Sachs GA, Hendrie HC. Integrating care for older adults with cognitive impairment. Curr Alzheimer Res. 2009 Aug;6(4):368-74. Review.
- Guerriero Austrom M, Damush TM, Hartwell CW, Perkins T, Unverzagt F, Boustani M, Hendrie HC, Callahan CM. Development and implementation of nonpharmacologic protocols for the management of patients with Alzheimer`s disease and their families in a multiracial primary care setting. Gerontologist. 2004 Aug;44(4):548-53.