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Alzheimer's Disease Multiple Intervention Trial

  • Completed

The purpose of this study is to conduct a 2-year, randomized, controlled clinical trial to improve functioning among older adults with Alzheimer's disease. The trial will compare a control group receiving best practices primary care with an intervention group receiving best practices primary care plus a home-based occupational therapy intervention.

Minimum Age Maximum Age Gender Healthy Volunteers
45 Years N/A Both No
July 2010
June 2015
180

Participants

++Current patient at Wishard Health Services in central Indiana++Diagnosis of possible or probable Alzheimer's disease++Age 45 or older++English speaking++Hearing adequate to answer questions in person or by telephone++Community-dwelling (includes senior communities but not skilled nursing facilities)++Caregiver willing to participate in the study++Willing to receive home visits++Live in Indianapolis metro area and are planning to continue care at a primary care clinic

Caregivers

++Age 18 or older++English speaking++Hearing adequate to answer questions in person or by telephone++Community-dwelling++Willing to receive home visits

++Not a current patient at Wishard Health Services++Non-English speaking++Currently enrolled in another study++Non-community dwelling or residing in a skilled nursing facility

The current study will test a home-based intervention designed to slow the rate of functional decline among older adults with Alzheimer's disease. A previous clinical trial demonstrated the effectiveness of collaborative primary care for older adults with Alzheimer's. In the prior trial, guideline-level medical care resulted in improved quality of care and improved behavioral and psychological symptoms over 1 year among patients and their caregivers. Despite significant differences among study groups on neuropsychiatric test scores, no significant difference  in functional decline was found between groups. Both study groups experienced a significant decline in function over 18 months.

This study also builds on recently reported research that demonstrated the short-term efficacy of home-based occupational therapy among older adults with dementia. These trials showed that older adults with dementia, including Alzheimer's disease, can both participate in and benefit from occupational therapy-based interventions delivered in the home.

Name City State Zip Status Primary Contact
Wishard Health Services Indianapolis Indiana 46202

Regenstrief Institute, IU Center for Aging Research

  • National Institute on Aging (NIA) - NIH

Name Role Affiliation
Christopher M Callahan, MD Principal Investigator Indiana University School of Medicine

Name Phone Extension Email
Carrie S. Morris, MS, OTR 317-423-5639 cespangl@iupui.edu

Alzheimer`s Disease Multiple Intervention Trial