The purpose of this study is to conduct a 2-year, randomized, controlled clinical trial to improve functioning among older adults with Alzheimer's disease. The trial will compare a control group receiving best practices primary care with an intervention group receiving best practices primary care plus a home-based occupational therapy intervention.
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The current study will test a home-based intervention designed to slow the rate of functional decline among older adults with Alzheimer's disease. A previous clinical trial demonstrated the effectiveness of collaborative primary care for older adults with Alzheimer's. In the prior trial, guideline-level medical care resulted in improved quality of care and improved behavioral and psychological symptoms over 1 year among patients and their caregivers. Despite significant differences among study groups on neuropsychiatric test scores, no significant difference in functional decline was found between groups. Both study groups experienced a significant decline in function over 18 months.
This study also builds on recently reported research that demonstrated the short-term efficacy of home-based occupational therapy among older adults with dementia. These trials showed that older adults with dementia, including Alzheimer's disease, can both participate in and benefit from occupational therapy-based interventions delivered in the home.
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Geolocation is 39.7794767, -86.1700894
Wishard Health Services
Regenstrief Institute, IU Center for Aging Research
National Institute on Aging (NIA)
Christopher M Callahan, MD
Indiana University School of Medicine
Carrie S. Morris, MS, OTR