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Alzheimer Prevention Trials (APT) Webstudy


The Alzheimer Prevention Trials (APT) Webstudy is an online registry designed to accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia. After signing up, participants will go online to fill out a brief assessment of their cognitive abilities and complete a 20-minute test to assess their memory and thinking skills. The test will be repeated every three months, and participants will have access to their scores. Participants may also be invited for in-person testing at a clinical site, involving either a brain scan or a lumbar puncture (spinal tap) to look for beta-amyloid, a protein that accumulates abnormally in the brains of people with Alzheimer's disease. If those tests indicate higher risk, the participant may then be notified of clinical trials that he or she would be eligible for. Participants can take part in the program without volunteering for clinical trials.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 85 Years All Yes
December 20, 2017
April 30, 2022

  • Willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk

  • Evidence of dementia

For more information and to enroll, visit

University of Southern California

  • National Institute on Aging (NIA)
  • Brigham and Women's Hospital
  • Cleveland Clinic

Name Role Affiliation
Paul Aisen, MD Principal Investigator University of Southern California
Reisa Sperling, MD Principal Investigator Brigham and Women's Hospital
Jeffrey Cummings, MD Principal Investigator Cleveland Clinic

Name Phone Email
APT Webstudy Team 858-877-3135


Alzheimer Prevention Trials Webstudy