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Aging-Well: Remote Monitoring for Adults at Risk for Alzheimer's Disease


This observational study will use sensors in the home environment to capture changes in routine daily activities that may signal cognitive or functional decline in older adults with and without mild cognitive impairment (MCI).

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A All Yes
September 1, 2018
June 2023

  • Taking at least one medication daily
  • Living within 15 miles of study site
  • Vision and hearing corrected to normal

  • Neurodegenerative diseases or dementias, including Alzheimer's, Parkinson's, Huntington's, vascular dementia, Lewy body dementia, and frontotemporal dementia
  • Major neurological disorders (e.g., seizures/epilepsy, stroke or mini-stroke, multiple sclerosis, brain tumor, normal pressure hydrocephalus, brain infection, amyotrophic lateral sclerosis)
  • History of significant brain injuries (e.g., loss of consciousness greater than 10 minutes, permanent brain lesion, anoxic/hypoxic encephalopathy)
  • Major or uncontrolled/unstable physical condition or illness, inculding chronic kidney disease, uncontrolled diabetes, uncontrolled heart disease, uncontrolled chronic obstructive pulmonary disease, and cancer (unless removed/targeted through radiation)
  • History of major psychiatric disorders, including schizophrenia, schizoaffective disorder, bipolar disorder, obsessive-compulsive disorder, or post-traumatic stress disorder
  • Significant neurodevelopmental disorders, such as autism spectrum disorders, attention-deficit/hyperactivity disorder, or intellectual disability
  • Substance use disorder diagnosis or treatment within last year
  • Impaired cognition
  • Loss of use of hands or very limited mobility
  • Exposure to Agent Orange if showing symptoms
  • Chemotherapy

Participants will have a technology platform installed in their home environment for up to 4 years. The platform is designed to detect changes in daily activities, such as taking medications, using the computer, and driving, that could signal cognitive changes. It will include an electronic pillbox, software installed on the participants' home computer/laptop/tablet, and wireless sensors placed in their car. Participants will also complete baseline and annual study assessments and tests, as well as weekly and monthly online surveys. Researchers are investigating the approaches used in this study as a way to proactively identify and monitor increasing risks for worsening cognitive function.

Name City State Zip Status Primary Contact
The University of Minnesota and Minneapolis VA Health Care System
Minneapolis Minnesota 55417 Recruiting

Oregon Health & Science University
Portland Oregon 97239 Recruiting

Name Role Affiliation
Adriana Seelye, PhD Principal Investigator University of Minnesota; Minneapolis VA Health Care System
John Ferguson, PhD Co-Investigator University of Minnesota; Minneapolis VA Health Care System

Name Phone Email
Jessica Klinger 612-467-1249