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Find more clinical trials

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Start: July 5, 2018
End: May 2024
Enrollment: 128

What Is This Study About?

Combining aerobic exercise and cognitive training, this study will compare the effects of cycling and cognitive training alone and together in older adults with mild cognitive impairment (MCI). Participants will be randomly assigned to one of four groups: 1) cycling on a recumbent stationary cycle, 2) cognitive training on a computer, 3) combined cycling and cognitive training, or 4) stretching and mental stimulation. Each group will complete their activity three times a week for six months. Researchers will track changes in cognition, including memory and thinking skills, as well as changes in fitness levels, brain changes measured by MRI, and any progression to MCI or Alzheimer's disease.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: N/A

Must have:

  • Diagnosis of MCI
  • Community-dwelling (does not live in long-term care facility)
  • English speaking
  • Adequate visual ability
  • Verified exercise safety by medical provider
  • Stable on drugs affecting cognitive and psychological status
  • Verified magnetic resonance imaging (MRI) safety, including no metal implants or pacemakers

Must NOT have:

  • Geriatric Depression Scale score less than 5
  • Resting heart rate of 50 or less due to arrhythmia or 100 or more beats per minute
  • Condition in the past five years that is a main contributor to MCI, including neurological (dementia, head trauma), psychiatric (bipolar, schizophrenia, depression), or substance dependency (alcohol or chemical)
  • Conditions that may prevent exercising safety, such as unstable angina or recent surgery
  • New symptoms or diseases that have not been evaluated by a health care provider
  • Current enrollment in another intervention study related to cognitive improvement
  • Abnormal MRI findings

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Fang Yu, PhD
Hector Cervanes, MS

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Arizona
Arizona State University
Phoenix, AZ 85004
Recruiting
Hector Cervanes, MS
Minnesota
University of Minnesota
Minneapolis, MN 55455
Recruiting
Russell Spafford, MS
New York
University of Rochester
Rochester, NY 14642
Recruiting
Nicholas Verhoef, MS

Who Sponsors This Study?

Lead: University of Minnesota - Clinical and Translational Science Institute

Collaborator Sponsor

  • University of Rochester
  • Mayo Clinic
  • University of St Thomas

Source: ClinicalTrials.gov ID: NCT03313895

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An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health