4 Repeat Tauopathy Neuroimaging Initiative
- Active, not recruiting
The purpose of this study is to identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time. Researchers will evaluate several different tests, including brain imaging, eye movement, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence, in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|45 Years||90 Years||Both||No|
- Clinical diagnosis of PSP or CBD
- Reliable study partner who has frequent contact with participant
- Significant neurological disease other than PSP or CBD
- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin. or body
In this observational study, investigators will use several different tests to identify which ones are most useful for tracking and analyzing PSP and CBD, two serious neurological diseases. Tests to be evaluated include brain imaging, eye movement, blood and cerebrospinal fluid samples, measurements of memory and other thinking abilities, and measures of functional independence. The long-term goal is to develop biomarkers that can provide precise, direct measures of the state of the brain, which will help improve clinical trials and, ultimately, treatment for these disorders.
|University of California, San Francisco||San Francisco||California||94158||
- National Institutes of Health (NIH) - NIH
- National Institute on Aging (NIA) - NIH
|Adam L. Boxer, MD, PhD||Principal Investigator||University of California, San Francisco|
|Lisa B. Voltarelli||415-476-9578||LVoltarelli@memory.ucsf.edu|
- Lee SE, Rabinovici GD, Mayo MC, Wilson SM, Seeley WW, DeArmond SJ, Huang EJ, Trojanowski JQ, Growdon ME, Jang JY, Sidhu M, See TM, Karydas AM, Gorno-Tempini ML, Boxer AL, Weiner MW, Geschwind MD, Rankin KP, Miller BL. Clinicopathological correlations in corticobasal degeneration. Ann Neurol. 2011 Aug;70(2):327-40. doi: 10.1002/ana.22424.
- Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin