Alzheimer's Disease Education and Referral Center

4 Repeat Tauopathy Neuroimaging Initiative

4 Repeat Tauopathy Neuroimaging Initiative

Overall Status: 
Brief Description: 

The purpose of this study is to identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time. Researchers will evaluate several different tests, including brain imaging, eye movement, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence, in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
45 Years
90 Years
Inclusion Criteria: 
    • Clinical diagnosis of PSP or CBD
    • Reliable study partner who has frequent contact with participant
Exclusion Criteria: 
    • Significant neurological disease other than PSP or CBD
    • Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin. or body
Detailed Description: 

In this observational study, investigators will use several different tests to identify which ones are most useful for tracking and analyzing PSP and CBD, two serious neurological diseases. Tests to be evaluated include brain imaging, eye movement, blood and cerebrospinal fluid samples, measurements of memory and other thinking abilities, and measures of functional independence. The long-term goal is to develop biomarkers that can provide precise, direct measures of the state of the brain, which will help improve clinical trials and, ultimately, treatment for these disorders.

Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 37.7748363, -122.3872576

San Francisco
Name: Dan Luong
Phone: 415-476-9578
Lead Sponsor: 
University of California, San Francisco
Collaborator Sponsor: 
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Facility Investigators: 
Adam L. Boxer, MD, PhD
Principal Investigator
University of California, San Francisco
Study Contact: 
Lisa B. Voltarelli
Locations ID 
NCT01804452 (follow link to view full record on in new window)
Official Title: 
Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration
Study Start Date: 
January 2011
Study End Date: 
August 2016
Trial References: