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Find more clinical trials

Physical Activity and Alzheimer's Disease (PAAD-2)

Start: May 23, 2019
End: December 2023
Enrollment: 240

What Is This Study About?

This study will test a one-year exercise program in middle-aged adults who have normal cognition and a family history of Alzheimer's disease. Researchers are investigating how exercise effects cognitive performance and whether those effects are influenced by APOE e4, a genetic variant that increases risk for Alzheimer's disease. Half of participants will engage in virtual exercise sessions with an instructor three days a week for one year. The other half will maintain their normal lifestyle, but will receive a health newsletter and be contacted regularly to talk about their health and physical activity. After study completion, they will receive a short-term fitness center membership. All participants will undergo MRI, a blood test, and assessments to measure cognitive performance.

Do I Qualify To Participate in This Study?

Minimum Age: 40 Years

Maximum Age: 65 Years

Must have:

  • Family history of Alzheimer's disease and/or cognitive impairment
  • Able to communicate in English
  • Not currently meeting recommendations for physical activity (3 days per week for 30 or more minutes per day) for longer than 3 months

Must NOT have:

  • Cognitively impaired
  • Unable to exercise due to known heart, metabolic, or kidney disease or to orthopedic limitations
  • Neurologic, psychiatric, medical, or any other condition that might limit exercise or pose a danger to the participant
  • Use of Alzheimer's medications or medications that adversely affect cognition or impact heart rate
  • Depression, as measured using the Center for Epidemiological Studies Depression Scale
  • Traveling for longer than a month during the course of the study

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Jennifer Etnier, PhD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

North Carolina
University of North Carolina-Greensboro
Greensboro, NC 27402
Recruiting
Jennifer Etnier, PhD

Who Sponsors This Study?

Lead: University of North Carolina, Greensboro

Collaborator Sponsor

  • Wake Forest University Health Sciences
  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03876314

alzheimers.gov

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health