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Find more clinical trials

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Start: April 3, 2018
End: October 31, 2020
Enrollment: 40

What Is This Study About?

This study will explore the use of transcranial magnetic stimulation (TMS) integrated with functional magnetic resonance imaging (fMRI) for diagnosing preclinical dementia and support development of a more sensitive diagnostic tool for dementia. TMS is a noninvasive approach to stimulate the brain. fMRI, which measures the brain's functional connectivity patterns, will be conducted when the brain is in a resting state, before and after the TMS procedure. Participants will undergo the TMS and fMRI procedures in a single day visit.

Do I Qualify To Participate in This Study?

Minimum Age: 60 Years

Maximum Age: 75 Years

Must have:

Participants with mild cognitive impairment:

  • Cognitive concern expressed by a physician, informant, participant, or nurse
  • Impairment in one or more cognitive domains (memory, language, visuospatial skills, or executive functions)
  • Essentially normal functional activities
  • Absence of dementia
  • Mini-Mental State Exam (MMSE, Appendix 19) scores of 18 to 23
  • Clinical Dementia Rating Scale score of 0.5

Healthy participants will be screened with the MMSE.

Must NOT have:

  • Contraindications to MRI
  • Contraindications to TMS
  • History of stroke
  • Clinical diagnosis of dementia
  • Diagnosis of neuropsychiatric disorder
  • Lefthandedness

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Arizona

Source: ClinicalTrials.gov ID: NCT03652012

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An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health