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Find more clinical trials

Natural History Study of Synucleinopathies

Start: June 2011
End: December 2024
Enrollment: 800

What Is This Study About?

In this study, researchers will document the clinical features and biomarkers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy) and those in a pre-dementia stage to better understand how these disorders evolve over time. Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and abnormal accumulation of the protein alpha-synuclein in the nervous system. Researchers will follow people diagnosed with a synucleinopathy and those believed to be in a pre-dementia stage over a 5-year period. The study aims to find biological clues of disease progression that would allow for testing of disease-modifying strategies to delay or stop the neurodegenerative process. 

Do I Qualify To Participate in This Study?

Minimum Age: 18 Years

Maximum Age: N/A

Must have:

  • Referred to any study site with orthostatic intolerance (dizziness or lightheadedness when standing that disappears when lying face upward)

Must NOT have:

  • Diabetes
  • Congestive heart failure
  • Lupus or other collagen vascular disease
  • Systemic illness thought to be responsible for orthostatic intolerance
  • Drug-induced orthostatic hypotension (e.g., the use of alpha-blockers, diuretics, and/or tricyclic antidepressants)
  • Isolated vasovagal syncope (fainting as a result of a sudden drop in blood pressure and heart rate)

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Horacio Kaufmann, MD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Massachusetts
Beth Israel Deaconess Medical Center
Boston, MA
Recruiting
Sharika Rajan
Michigan
University of Michigan
Ann Arbor, MI
Recruiting
Arijit Bhaumik, BA
Minnesota
Mayo Clinic
Rochester, MN
Recruiting
Tonette Gehrking
New York
NYU Medical Center
New York, NY 10016
Recruiting
Jose Martinez, MA
Tennessee
Vanderbilt Univeristy
Nashville, TN
Recruiting
Emily Garland, PhD

Who Sponsors This Study?

Lead: New York University School of Medicine

Source: ClinicalTrials.gov ID: NCT01799915

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