Start:
June 2015
End:
December 2022
Enrollment:
150
Calorie restriction is defined as consuming fewer calories than what is considered normal without a lack of nutrients. This study will investigate how calorie restriction affects insulin resistance, weight, and brain chemicals related to Alzheimer's disease. The intervention group will adopt a 5-2 CR diet (500-600 calories a day for two consecutive days, followed by unrestricted eating for five days) for eight weeks. The control group will eat a normal, unrestricted diet. Both groups will receive dietary counseling at the start of the study. A visit at the beginning and end of the study will involve anthropometric measures, questionnaires, cognitive tests, a brain scan, blood draws, and lumbar puncture. Participants will visit the clinic every two weeks to be weighed and have a blood draw. Participants will wear an accelerometer, which measures physical activity, for 96 hours before and after they are on the diet.
Minimum Age: 55 Years
Maximum Age: 70 Years
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Lead: National Institute on Aging (NIA)
Source: ClinicalTrials.gov ID: NCT02460783
An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health