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Brad Wise
Title: Chief, Neurobiology of Aging and Neurodegeneration Branch
Office(s): Division of Neuroscience (DN)
Phone Number: 301-496-9350
Email Address:


Dr. Wise is Chief of the Neurobiology of Aging and Neurodegeneration Branch in the Division of Neuroscience. He oversees the administration, coordination, and development of research on fundamental neuroscience of aging, basic science of Alzheimer’s disease and related diseases, integrative neurobiology, and sleep disorders and biological rhythms. He manages a portfolio on the basic science of brain aging and neurodegeneration, selective vulnerability and plasticity, and stem cells.

Dr. Wise received his B.A. in Chemistry from Duke University and his Ph.D. in Pharmacology from Emory University School of Medicine. His postdoctoral training was at the National Institute of Mental Health intramural research program, first as a PRAT fellow and then staff fellow. Prior to joining the NIA in 1996, Dr. Wise was a laboratory chief in the Fidia-Georgetown Institute for the Neurosciences and a faculty member in the Department of Pharmacology at Georgetown University Medical Center, where he conducted research on the molecular and cellular mechanisms regulating neurotropic factors, particularly nerve growth factor.

Research Interests/Portfolio

  • Hallmarks and mechanisms – genetic, molecular, cellular, physiological – of brain aging and neurodegeneration
  • Selective cell, circuit and network vulnerability and plasticity
  • Neurogenesis, neural stem cells, and cell reprogramming
  • Mapping of neural cell types, molecules and connectivity
  • Brain structural and functional connectome