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reddish haired man in a collared shirt that is red with tan horizontal stripes
Title: Health Scientist Administrator
Office(s): Division of Aging Biology (DAB)
Phone Number: 301-496-6402
Email Address:


John Williams, Ph.D., is a physiologist, bone cell biologist, and program officer at the National Institute on Aging’s Division of Aging Biology in the Aging Physiology Branch. Dr. Williams was previously an associate professor in nephrology in the Department of Medicine at the University of Kentucky in Lexington, with a joint appointment in the Department of Physiology.

Dr. Williams received his doctorate from Oklahoma State University and post-doctoral training at Washington University in St. Louis. In 1993, Dr. Williams switched from insulin signal transduction to osteoclast biology and did research primarily on bone metabolism until 2007.

At NIA, Dr. Williams oversees the Kidney and Urogenital Program, the Bone and Cartilage Program, and the Reproductive and Endocrine Program in the Aging Physiology Branch of the Division of Aging Biology. He covers grants investigating the basic biology of muscle, bone, cartilage, and wound healing.

Research Interests/Portfolio

Kidney and Urogenital Program

  • Physiological basis of age-related kidney disease and kidney failure including decreased glomeruli function, nephrosclerosis, and susceptibility to injury
  • Systems biology approaches to understanding cell nonautonomous regulation of the aging kidney
  • Age-related changes in the function of the bladder, urethra, and prostate including the molecular basis and pathogenesis of incontinence, underactive bladder and prostate hyperplasia

Bone and Cartilage Program

  • Age-related changes in the cellular and matrix components of bone and cartilage
  • Understanding bone as an emerging endocrine tissue
  • Molecular basis of osteoporosis and osteoarthritis

Reproductive and Endocrine Program

  • Age-related changes in hormone production, metabolism, and action
  • Aging changes in the reproductive system, including hormonal changes and their consequences in non-reproductive tissues
  • Age-related changes in non-reproductive hormones and hormone action
  • Aging of the liver in disease and injury, in the exocrine functions of the pancreas and function of the gastrointestinal systems
  • Effects of aging on pancreas endocrine function and diabetes

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