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Christopher RAMSDEN

Christopher Ramsden, M.D., Chief
Title: Tenure Track Investigator
Office(s): Lipid Peroxidation Unit (HNN-25)
Phone Number: 410-558-8369
Email Address: ramsdence@mail.nih.gov

Biography

Dr. Ramsden is a Clinical Investigator in the Intramural Program of the NIH and CAPT in the Commissioned Corps of the U.S. Public Health Service. Following completion of a medical internship and residency training, Dr. Ramsden was a clinical research fellow at UNC-Chapel Hill before joining the Intramural Program of the NIAAA in 2009. In 2016, he was appointed to a Clinical Tenure-Track position as the Head of the Lipid Peroxidation Unit, within the Laboratory of Clinical Investigation in the NIA in Baltimore, MD, with a joint Tenure-Track appointment in the Intramural Program of NIAAA in Bethesda, MD. Dr. Ramsden currently leads an interdisciplinary, translational research program investigating the roles of lipid mediators and lipid-related mechanisms underlying the pathogenesis of chronic pain and Alzheimer’s disease.

Research Topics

The objectives of the Lipid Peroxidation Unit are: (1) to delineate the roles of lipid peroxidation and lipid-related degeneration in age-related diseases, with an emphasis on chronic pain and Alzheimer’s disease, and (2) to translate discoveries into targeted, safe and effective diet and drug-based treatments. The Unit applies an interdisciplinary, translational approach— comprising randomized controlled trials, postmortem studies using traditional and multiplex immunohistochemistry, synthetic and analytical chemistry, and cellular models—to achieve these objectives.

Selected Publications

Ramsden CE, Keyes GS, Calzada E, Horowitz MS, Zamora D, Jahanipour J, Sedlock A, Indig FE, Moaddel R, Kapogiannis D, Maric D. Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer's Disease in Humans. J Alzheimers Dis. 2022 Apr 16. doi: 10.3233/JAD-220071.

Ramsden CE, Zamora D, Faurot KR, MacIntosh B, Horowitz M, Keyes GS, Yuan Z, Miller V, Lynch C, Honvoh G, Park J, Levy R, Domenichiello AF, Johnston A, Majchrzak-Hong S, Hibbeln JR, Barrow DA, Loewke J, Davis JM, Mannes A, Palsson OS, Suchindran CM, Gaylord S, Mann JD. Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial. The BMJ. 2021; 374; n1448. https://www.bmj.com/content/374/bmj.n1448

Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ. A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Sci Signal. 2017;10(493).

Ramsden CE, Faurot KR, Zamora D, Suchindran CM, Macintosh BA, Gaylord S, Ringel A, Hibbeln JR, Feldstein AE, Mori TA, Barden A, Lynch C, Coble R, Mas E, Palsson O, Barrow DA, Mann JD. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013;154(11):2441-51.

Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ. 2016;353:i1246.

Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013;346:e8707.