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Christopher RAMSDEN

Christopher Ramsden, M.D., Chief
Title: Tenure Track Investigator
Office(s): Diabetes Section (DS)
Phone Number: 410-558-8369
Email Address: ramsdence@mail.nih.gov

Biography

Dr. Ramsden is a Clinical Investigator in the Intramural Program of the NIH, Commander in the Commissioned Corps of the U.S. Public Health Service (PHS), and Adjunct Faculty at UNC-Chapel Hill. After completing a medical internship and then residency training in Physical Medicine & Rehabilitation at the Rehabilitation Institute of Chicago, he was a clinical research fellow at UNC-Chapel Hill before joining the Intramural Program of the NIAAA in 2009. In 2016, he was appointed to a Clinical Tenure-Track position as the Head of the Lipid Peroxidation Unit, within the Laboratory of Clinical Investigation in the NIA in Baltimore, MD, with a joint Tenure-Track appointment in the Intramural Program of NIAAA in Bethesda, MD.  Dr. Ramsden leads an interdisciplinary, translational research program investigating the roles of lipid mediators and lipid-related mechanisms underlying the pathogenesis of age-associated diseases, with an emphasis on chronic pain and neurodegenerative conditions. Dr. Ramsden also serves as Chief Medical Officer for PHS-1 Rapid Deployment Force team of the Commissioned Corps.

Research Topics

The objectives of the Lipid Peroxidation Unit are: (1) to discover new mediators and mechanisms linking lipids to age-associated diseases, with an emphasis on chronic pain and Alzheimer’s disease, and (2) to translate these discoveries into targeted, safe and effective diet and drug-based treatments. The Unit applies an interdisciplinary, translational approach—comprising randomized controlled trials, non-randomized and postmortem studies, missing data recovery, synthetic and analytical chemistry, animal models, immunohistochemistry, and cellular and ex vivo assays—to achieve these objectives.

Selected Publications

Ramsden, C.E., Domenichiello A.F., Yuan Z.X., Sapio M., Keyes G.S., Mishra S.K., Gross J.R., Majchrzak-Hong S., Zamora D., Horowitz M.S., Davis J.M., Sorokin A.V., Dey A., LaPaglia D.M., Wheeler J., Vasko M.R., Mehta N.N., Mannes A.J., Iadarola M.J.  A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch. Sci Signal. 2017 Aug 22;10(493).

Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., MacIntosh, B. A., Gaylord, S., … Mann, J. D. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial. Pain, 154(11), 10.1016/j.pain.2013.07.028. doi: 10.1016/j.pain.2013.07.028

Ramsden, C. E., Zamora, D., Majchrzak-Hong, S., Faurot, K. R., Broste, S. K., Frantz, R. P., … Hibbeln, J. R. (2016). Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). The BMJ, 353, i1246.

Ramsden, C. E., Zamora, D., Leelarthaepin, B., Majchrzak-Hong, S. F., Faurot, K. R., Suchindran, C. M., … Hibbeln, J. R. (2013). Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. The BMJ, 346, e8707

Ramsden, C. E., Ringel, A., Majchrzak-Hong, S. F., Yang, J., Blanchard, H., Zamora, D., … Taha, A. Y. (2016). Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? Molecular Pain, 12.