Andras OROSZ

Biography

Andras Orosz, Ph.D., joined the Cell Biology Branch in the Division of Aging Biology in 2023 as a program director managing a research portfolio focused on the molecular basis of age-related changes in cellular microenvironment, signal transduction mechanisms, senescence, apoptosis, cell proliferation, translation, age-dependent protein damage and turnover. He obtained his Ph.D. from the Attila Jozsef University in Szeged, Hungary where he studied the transcriptional termination mechanism of the E. coli ribosomal RNA operon rrnB. He received postdoctoral training at The National Cancer Institute (NCI), Bethesda investigating the eukaryotic transcriptional master stress regulator Heat Shock Factor (HSF) in Drosophila. Subsequently, as a Research Fellow at NCI he examined the role of basic leucine zipper transcription factors in lipoatrophic diabetes, carcinogenesis and addiction. Between 2005-2008 he has been a research instructor at the Cardiology Division at the University of Utah Health Sciences Center in Salt Lake City, Utah where his research focused on elucidating the cardioprotective functions of Heat Shock Proteins (HSPs) and Heat Shock Factor 1 (HSF1). Before joining the National Institute on Aging he has been a program director at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) from 2008 to 2023. He managed a diverse portfolio overarching a broad range of alcohol induced pathologies including the cardiovascular system, aging, protein homeostasis (proteostasis), alcohol associated liver disease, epigenetics, mitochondrial dysfunction, bone health and alcohol biomarkers. He is the founder and co-chair of the trans-NIH Scientific Interest Group “Proteostasis”.