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Julie Mattison

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Title: Staff Scientist II
Office(s): Experimental Gerontology Section (EGS)
Phone Number: 301-435-7637
Email Address:


Dr. Julie Mattison earned a Bachelor’s degree in Biology from the University of California, San Diego and followed with a Master’s degree in Exercise Physiology from Central Washington University. She received her Ph.D. in the laboratory of Dr. Andrzej Bartke in Animal Physiology at Southern Illinois University, Carbondale. She studied the effect of growth hormone on metabolism, health, and longevity, and then launched into the field of calorie restriction. She joined the National Institute on Aging as a post-doctoral fellow in 2000 continuing her work on calorie restriction. She is currently a Staff Scientist/Facility Head of the Nonhuman Primate Core within the Translational Gerontology Branch.

Research Interests/Portfolio

The NIA Nonhuman Primate Core was established in 2012 to support the experimental goals of intramural investigators and extramural collaborators. The Core offers research services supporting multi-disciplinary translational aging projects and a tissue bank. The Core guides study design and conducts short-term intervention studies (e.g., dietary, drug, exercise) to evaluate putative biomarkers of aging, pharmacodynamics, and proof of concept projects.


Selected Publications

Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, and de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature, 2012; 489(7415): 318-321. doi: 10.1038/nature11432.

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, de Cabo R, and Anderson RM. Caloric restriction improves health and survival of rhesus monkeys. Nat Commun, 2017; 8: 14063. doi: 10.1038/ncomms14063.

Li Y, Vaughan KL, Tweedie D, Jung J, Kim HK, Choi HI, Kim DS, Mattison JA, and Greig NH. Pharmacokinetics of Exenatide in nonhuman primates following its administration in the form of sustained-release PT320 and Bydureon. Sci. Rep., 2019; 9(1): 17208. doi: 10.1038/s41598-019-53356-2.

Stonebarger GA, Urbanski HF, Woltjer RL, Vaughan KL, Ingram DK, Schultz PL, Calderazzo SM, Siedeman JA, Mattison JA, Rosene DL, and Kohama SG. Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques. Geroscience, 2020; 42:1733. doi: 10.1007/s11357-020-00259-0. Epub 2020/09/03

Horvath S, Zoller JA, Haghani A, Jasinska AJ, Raj K, Breeze CE, Ernst J, Vaughan KL, Mattison JA. Epigenetic clock and methylation studies in the rhesus macaque. GeroScience 2021; 43:2441. doi: 10.1007/s11357-021-00429-8.

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