Dr. Maragkakis received his bachelor's degree in Physics from the University of Athens where he focused on computational simulation of neuronal action potentials and signal processing. He received his PhD in a joint program between Biomedical Science Research Center "Alexander Fleming" and Martin Luther University of Halle-Wittenberg. His PhD research involved the analysis and development of microRNA (miRNA) gene target prediction algorithms and the functional analysis of miRNA targeting. He then joined the laboratory of Dr. Zissimos Mourelatos at the University of Pennsylvania where he completed his postdoctoral research work on computational genomics, post-transcriptional gene regulation, RNA-binding proteins and co-translational mRNA decay. He joined the NIA in 2019 as a Stadtman Tenure-Track Investigator where he leads the Computational Genomics Unit.
Understanding the high-dimensional regulation in cells as a key component of discovering the mechanistic basis of human disease and aging. Combining experimental and computational approaches to discover fundamental biological mechanisms of RNA stability and dynamics. Integrating high-throughput short and long-read sequencing data and machine learning to decipher regulatory networks in cells and their changes across aging.