Mack MACKIEWICZ
Title:
Program Director
Office(s):
Division of Neuroscience (DN)
Phone Number:
301-594-7636
Email Address:
miroslaw.mackiewicz@nih.gov
Biography
Dr. Mack Mackiewicz is a Program Director in the Neurobiology of Aging and Neurodegeneration Branch in the Division of Neuroscience. Dr. Mackiewicz received his M.S. in microbiology and genetics from Warsaw University, Poland, and his Ph.D. in genetics from the National Cancer Institute in Warsaw, Poland. Prior to joining NIA in 2009, Dr. Mackiewicz was a faculty member in the Department of Medicine, University of Pennsylvania School of Medicine in Philadelphia, where he conducted research on the cellular and molecular mechanisms regulating sleep and the circadian clock. At NIA, Dr. Mackiewicz is responsible for research on integrative neurobiology, sleep and biorhythms.
Research Interests/Portfolio
- Mechanisms of age-related alterations in communication between peripheral organ systems and central and peripheral nervous systems
- The impact of alterations in communication between peripheral organ systems and central and peripheral nervous systems on normal and pathological and aging of the nervous system
- Mechanisms that modulate alterations in communication between peripheral organ systems and central and peripheral nervous systems that impact neurodegenerative processes
- Molecular, cellular, genetic, epigenetic, and systems biology approaches to advance basic and clinical research on the causes and consequences of sleep deficiency and circadian clock dysfunction in Alzheimer's disease and the roles of sleep and the circadian clock as modifiers of the progression of neurodegeneration
- Research on the integrative physiology of sleep in aging and whether disruption of sleep and/or circadian clock accelerates brain aging and Alzheimer’s disease neurodegenerative change; the short- and long-term consequences of disrupted and optimized sleep on brain aging and Alzheimer’s disease
- Research to understand the underlying mechanisms of sleep deficiencies among U.S. populations that experience health disparities and how sleep deficiencies may lead to disparities in health outcomes