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Mack Mackiewicz
Title: Program Director
Office(s): Division of Neuroscience (DN)
Phone Number: 301-594-7636
Email Address:


Dr. Mack Mackiewicz is a Program Director in the Neurobiology of Aging and Neurodegeneration Branch in the Division of Neuroscience. Dr. Mackiewicz received his M.S. in microbiology and genetics from Warsaw University, Poland, and his Ph.D. in genetics from the National Cancer Institute in Warsaw, Poland. Prior to joining NIA in 2009, Dr. Mackiewicz was a faculty member in the Department of Medicine, University of Pennsylvania School of Medicine in Philadelphia, where he conducted research on the cellular and molecular mechanisms regulating sleep and the circadian clock. At NIA, Dr. Mackiewicz is responsible for research on integrative neurobiology, sleep and biorhythms.

Research Interests/Portfolio

  • Neural mechanisms underlying age-related changes in endocrine and immune functions in aging and neurodegenerative diseases
  • Neurodegenerative diseases of aging associated with viral infections
  • Molecular and cellular mechanisms of age-related changes in sleep and circadian function, and the effects of sleep deficiency and circadian disruption on the onset and progression of neurodegenerative diseases
  • Research on aging and disease-driven changes in the structure and function of brain microvasculature
  • Molecular mapping of brain cell types and connectivity in aging