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Ajoy Karikkineth

Ajoy Karikkineth
Title: Staff Clinician
Office(s): Office of the Scientific Director (OSD)
Email Address: ajoy.karikkineth@nih.gov

Biography

Dr. Ajoy Karikkineth is a Board-Certified Internist. His interest in cardiovascular research and aging led him to being part of the Baltimore Longitudinal Study of Aging (BLSA) staff. His early work related to investigating the longitudinal progression of intimal medial wall thickness and factors affecting it. Subsequently, his research interests have expanded to the associations between cardiovascular disease and mobility.

Portfolio

Dr. Karikkineth’s research focuses on the association of cardiovascular risk factors with mobility and physical performance. The impact of cardiovascular disease on physical performance is important because physical performance is an indicator of physiologic reserve, and impairment of physical performance is associated with greater morbidity, worse prognosis in many clinical conditions, and increased mortality. Examples of specific topics that Dr. Karikkineth is presently studying are the association of pulse wave velocity and pulse pressure with gait variability, and the impact of high pulse wave velocity and ankle-brachial index on spatiotemporal variables of gait cycle. His work also includes exploring the different mechanisms for these associations, including the role of cognition, changes in muscle, and peripheral nerve damage.

Related scientific focus areas

  • Clinical research
  • Epidemiology
  • Cardiovascular research

Selected publications

  1. Karikkineth, Ajoy C. Healthcare Provisions in an Aging Society. In Developing Drugs in an Aging Society- From Concept to Prescribing, 3-22: Springer International Publishing, 2016
  2. Karikkineth AC, Scheibye-Knudsen M, Fivenson E, Croteau DL, Bohr VA. Cockayne syndrome: Clinical features, model systems and pathways. Ageing Res Rev. 2017 Jan;33:3-17. doi: 10.1016/j.arr.2016.08.002. Epub 2016 Aug 6. Review. PubMed PMID: 27507608; PubMed Central PMCID: PMC5195851
  3. Karikkineth, Ajoy C., Marco Canepa, Palchamy Elango, James B. Strait, Edward G. Lakatta, and Luigi Ferrucci. “C–Reactive Protein as a predictor of intimal media thickness in a healthy community dwelling population of a broad age.” Journal of the American College of Cardiology 61, no. 10 (March 12, 2013): E2030. doi:10.1016/S0735-1097(13)62030-6.
  4. Jamal, Sameer M., James Strait, Osorio Meirelles, Jun Ding, Lindsay D. Mehring, Brett Sperry, Abdulghani Saadi, et al. “Early repolarization pattern: Clinical correlates of specific electrocardiographic subtypes and genome wide association study of a Sardinian population.” Journal of the American College of Cardiology 59, no. 13, Supplement (March 27, 2012): E719. doi:10.1016/S0735-1097(12)60720-7.