Magdalena is a Visiting Fellow in the Oxidative DNA Damage Process and Mitochondria Functions Unit of the Laboratory of Molecular Gerontology
I am a joint postdoctoral fellow in the Laboratory of Molecular Gerontology and the Laboratory of Neurosciences. My research concentrates on the role of DNA repair in brain aging and neurodegenerative disorders such as Alzheimer’s disease. In particular I am testing the hypothesis that inefficient DNA repair due to DNA Polymerase deficiency can lead to disruptions in neural stem cell proliferation, differentiation and cellular metabolism during brain development and adult neurogenesis. Adult neurogenesis occurs in the olfactory bulb as well as dentate gyrus of the hippocampus, the brain area responsible for short term memory which is affected in Alzheimer’s disease. Loss of olfaction occurs during normal aging and is one of the first symptoms in patients with Alzheimer’s and Parkinson’s diseases; Therefore understanding the role of DNA Polymerase and DNA repair in maintaining proper function of the hippocampus and olfactory bulb may lead to new approaches for preventing and treating neurodegenerative disorders.
Publications by Magdalena Misiak on PubMed