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Dr. John Hsiao
Title: Program Director
Office(s): Division of Neuroscience (DN)
Phone Number: 301-496-9350
Email Address:


Dr. John Hsiao, a psychiatrist trained in Nuclear Medicine, is Program Director of the Dementia Diagnosis and Biomarkers Program in the Clinical Interventions and Diagnostics Branch of the Division of Neuroscience at the National Institute on Aging. He is also a Captain (Retired) in the U.S. Public Health Service where he served for 30 years. He oversees a large research portfolio that includes biomarkers, diagnosis and neuroimaging of Alzheimer’s disease.

Dr. Hsiao received his M.D. from the University of Maryland and trained in psychiatry at the University of North Carolina and NIH. As an NIGMS PRAT Fellow, he studied microdialysis in animals, then completed Nuclear Medicine training in the NIH Clinical Center. He was with the NIMH Intramural and Extramural Research Programs for 23 years. There he led the NIMH’s flagship CATIE Schizophrenia and Alzheimer’s Trials (randomized clinical trials comparing atypical antipsychotics), initiated the RAISE (Recovery After an Initial Schizophrenic Episode) project, and served as Editor-in-Chief of Schizophrenia Bulletin. He joined NIA in 2009.

He has authored or co-authored more than 90 scientific papers, in journals including the Journal of Neurochemistry, Journal of the American Medical Association and New England Journal of Medicine. Outside of his work at NIH, Dr. Hsiao is a clinical psychiatry consultant specializing in psychopharmacology and dementia.

Research Interests/Portfolio

  • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
  • Biomarkers of Cognitive Decline Among Normal Individuals: The BIOCARD Cohort
  • Neurodegeneration in Aging Down Syndrome (NIAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease
  • Wisconsin Registry for Alzheimer's Prevention

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