Dr. Amanda DiBattista is a Program Director in the Fundamental Neuroscience Section of the Neurobiology of Aging and Neurodegeneration Branch in the Division of Neuroscience. Dr. DiBattista earned her B.A. in Neuroscience from the University of Virginia, and she earned her Ph.D. in Neuroscience from Georgetown University. Prior to joining NIA in 2017, her research at Georgetown University focused on understanding how the APOE4 gene increases the risk for Alzheimer’s disease using molecular, cellular and behavioral approaches. Dr. DiBattista is responsible for overseeing research on the role of neuroplasticity, glia and lipid neurobiology in the aging brain.
- Mechanisms underlying the plasticity of neural cells in brain aging, including cell level changes, LTP/LTD, neurotransmitter receptors and synaptic dysfunction
- Neural mechanisms associated with age-related changes in glia and other non-neuronal cells, including microglia, astrocytes, oligodendrocytes, oligodendrocyte progenitor cells (OPCs), neural progenitor cells (NPCs) and endothelial cells
- Role of lipid signaling and metabolism in brain aging and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD), including the role of APOE
- Cellular senescence in brain aging and AD/ADRD