Dr. Demarest received his Ph.D. in neuroscience from the University of Maryland School of Medicine and is a joint postdoctoral fellow in the Laboratory of Molecular Gerontology and the Laboratory of Neurosciences
My research focuses on the influence of brain mitochondrial metabolism and quality control in normal aging and age-related disorders like stroke and Alzheimer’s disease. In addition to providing the majority of cellular energy, mitochondria are the only organelle (apart from the nucleus) that have their own DNA. Mitochondrial DNA damage accumulates throughout the lifespan, but mitochondrial DNA repair mechanisms are not well understood. Therefore, I am working on understanding the relationship between brain mitochondrial metabolism and mitochondrial DNA repair in the context of aging and age-related neurodegeneration. I am also interested in testing interventions that promote optimal mitochondrial efficiency and healthy aging.