Role of ApoE and its Receptors in Normal Brain Aging and in Alzheimer's Disease
The Division of Neuroscience (DN), organized a multidisciplinary advisory workshop on “The Role of ApoE and its Receptors in Normal Brain Aging and in Alzheimer’s Disease” held in Bethesda, MD, on August 13-14, 2008. ApoE is a pleiotropic protein which regulates multiple metabolic and signaling pathways in the periphery and in the Central Nervous System, and, in addition, is a ligand for a number of receptors. The purpose of this workshop was to examine the current state of knowledge concerning the biology of ApoE and its receptors with an emphasis on their role in normal brain aging and in Alzheimer’s Disease (AD). A major subject of discussion was advances and challenges in the drug discovery arena aimed at ApoE as a therapeutic target, with the goal of identifying new avenues for future investigation.
Dr. Suzana Petanceska