Symptoms

Falls may be sign of future Alzheimer’s disease, cognitive decline

Cognitively normal older adults with evidence of early brain changes typical of Alzheimer’s disease fell more often than did their peers without these brain changes, a new study reported online in Neurology. The results suggest that declines in mobility may precede the symptoms of cognitive decline found in Alzheimer’s disease.

Latest NIH Alzheimer’s research progress report available

A new online report from the National Institutes of Health (NIH) highlights recent progress in NIH-supported Alzheimer’s disease research.

Prepared annually by the National Institute on Aging (NIA) at NIH, the latest report -- 2011-2012 Alzheimer’s Disease Progress Report: Intensifying the Research Effort -- describes new investments and summarizes research in several areas:

Part 2: What Happens to the Brain in AD

The Hallmarks of AD

Alzheimer’s disease disrupts critical metabolic processes that keep neurons healthy. These disruptions cause nerve cells in the brain to stop working, lose connections with other nerve cells, and finally die. The destruction and death of nerve cells causes the memory failure, personality changes, problems in carrying out daily activities, and other features of the disease.

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Alzheimer's Disease Fact Sheet

Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest tasks. In most people with Alzheimer’s, symptoms first appear after age 60. Estimates vary, but experts suggest that as many as 5.1 million Americans may have Alzheimer’s disease.

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Alzheimer's Disease: Unraveling the Mystery

An essential primer on Alzheimer’s disease, this 80-page publication describes how the brain works and how it changes with age in healthy people and people with Alzheimer’s. Research on causes, diagnosis, prevention, potential treatments, and caregiver support is summarized. Look for full-color illustrations, a glossary, and a list of resources.

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Understanding Memory Loss

What To Do When You Have Trouble Remembering

Image of older African-American couple sitting on sofaLearn the difference between mild forgetfulness and more serious memory problems in this 24-page booklet. Also discussed are various causes of memory problems and how to get help for serious memory loss.

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Understanding Alzheimer's Disease

This 19-page easy-to-read booklet describes what happens when someone has Alzheimer’s disease and how it differs from normal aging. Read about when to see the doctor, possible treatments, and how patients and caregivers can get help.

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Forgetfulness: Knowing When To Ask For Help

Many people worry about becoming forgetful. They think forgetfulness is the first sign of Alzheimer's disease. Over the past few years, scientists have learned a lot about memory and why some kinds of memory problems are serious but others are not.

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Subjective cognitive impairment could be precursor of further decline

The cognitive health of older adults with “subjective cognitive impairment” (SCI) declined faster and further than that of people without SCI over a period of years, a recent study found. The study suggests that very early, subtle changes in memory in people who test as cognitively normal might predict more serious types of impairment.

Hypothesis for cause of memory loss in Alzheimer's disease proposed

An unexpected discovery by researchers at The National Institutes of Health (NIH), may help to explain how Alzheimer's disease causes memory loss. The research shows that beta amyloid, a common protein in the brain, can make cell membranes leak choline, and thus reduce production of acetylcholine in cells. Choline, an essential ingredient in acetylcholine, has been known for many years to help store and retrieve memories. Two hallmarks of Alzheimer's disease are accumulation in the brain of beta amyloid and reduction of the concentration of acetylcholine.

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