NIA maintains colonies of aged rats and mice for use by the scientific community for research directly related to aging and age-related diseases. The animals are housed behind specific pathogen-free barriers and monitored for genetic purity and health status, and a health report accompanies each shipment of animals. In addition, NIA supports a tissue bank of flash frozen tissues from mice and rats from the aged rodent colonies and tissue arrays containing punches of multiple ages and multiple tissues per slide. Please note that there are restrictions on eligibility to use the NIA aged rodent colonies.
NIA maintains approximately 150 nonhuman primates (Macaca mulatta) at four regional primate centers for conducting research on aging. These animals range in age from 18 to 35 years. These rhesus monkeys are currently only approved for noninvasive research. The NIA Biological Resources Branch (BRB) has developed a compendium of nonhuman primate resource availability for aging research. Contact the BRB for a copy.
The Nonhuman Primate Tissue Bank provides a source of archived tissue from aged nonhuman primates, primarily rhesus monkeys. The tissue is donated by primate centers and universities with primate colonies and is available as frozen tissue chunks, slides of fixed tissue sections, and OTC-embedded frozen tissues.
The NIA supports the Primate Aging Database (PAD), a searchable database that contains basic health and husbandry data from primates across the lifespan and from numerous research institutions. PAD, hosted by the Wisconsin National Primate Center, is a password-secured site. For information, go to http://ipad.primate.wisc.edu.
This webpage describes a network of NIA grantees willing to share resources that support comparative biology of aging studies.
NIA supports a multi-institutional study investigating diets and dietary supplements purported to extend lifespan and delay disease and dysfunction. ITP allows investigators to submit proposals for interventions to be tested for their ability to decelerate aging and extend lifespan in mice.
NIA supports studies of human aging that have collections of biospecimens available for sharing. The Virtual Repository is a Web site that provides a central portal to these studies, with introductory information on participating studies.
NIA also provides partial support for the C. elegans Genetic Center, located at the University of Minnesota. This stock center contains more than 1,000 strains of C. elegans, many of which are useful in studying aging.
To facilitate aging research on cells in culture, the NIA provides support for the NIA Aging Cell Repository, located at the Coriell Institute for Medical Research in Camden, NJ. Included are skin fibroblast cultures from individuals with premature aging syndromes, including Werner and Hutchinson-Guilford (progeria), cultures from clinically documented and at-risk individuals from families exhibiting familial Alzheimer's disease, differentiated cell lines, and cell lines from animals. The repository also has DNA from many of the cell lines, available individually or in panels such as the Primate DNA panel, Aging Syndrome DNA panel, Characterized Alzheimer's disease mutation DNA panel, Early and Late Onset Alzheimer's disease DNA panels, and Aged Sib Pairs DNA panel.
The NIA Clinical Research Study Investigators Toolbox provides a Web-based information repository for investigators and staff involved in clinical research. The Toolbox contains templates, sample forms, guidelines, regulations and information materials to assist investigators in the development and conduct of high quality clinical research studies.
Clinicians and researchers can use this searchable database to identify published instruments for use in their outpatient practice or community studies. The database, which contains information about 134 instruments, was created by NIA staff, in consultation with experts in the field.
NIH Toolbox is a multidimensional set of brief measures assessing cognitive, emotional, motor and sensory function from ages 3 to 85, meeting the need for a standard set of measures that can be used as a “common currency” across diverse study designs and settings.
The Patient-Reported Outcomes Measurement Information System (PROMIS) is an NIH-funded initiative to develop and validate patient reported outcomes (PROs) for clinical research and practice. PROMIS aims to enhance and standardize measurement of several selected PROs through both computer adaptive testing and traditional "paper and pencil" instruments.
PROMIS was established in 2004 as a cooperative network that developed and validated PROs in global health, physical function, fatigue, pain, sleep/wake function, emotional distress, and social health. Currently, the PROMIS network consists of 12 research sites and 3 administrative centers that are developing PROs in several new domains and performing validation studies of PROs in new and existing domains.
PROMIS is one of several initiatives under the NIH Roadmap. Researchers and clinicians are encouraged to consider using PROMIS tools in their studies or practices. More information about PROMIS, including item banks, PRO instrument forms, and Assessment Center™, is available at www.nihpromis.org.
NIA-relevant questions about PROMIS may be directed to:
Basil Eldadah, MD, PhD
Phone: (301) 496-6761
A searchable database for epidemiologic research on aging changes across the lifespan.