Laboratory Analytes and Repository Plan - Health ABC
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Examination 1 N=32121 |
Examination 2 N=27341 |
Examination 3 N=27341 |
Examination 4 N=2850 |
Examination 5 N=2800 |
Examination 6 N=2800 |
Examination 7 N=2800 |
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| Stored specimens: |
1 extracted DNA, microtiter plates
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cells for later transformation
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| Stored specimens: |
19 aliquots serum2
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10 aliquots serum
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4 serum
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4 serum
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10 serum
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| Stored specimens: |
12 aliquots EDTA plasma3
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10 aliquots EDTA
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4 citrated
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7 plasma
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10 plasma
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| Stored specimens: |
4 aliquots citrated plasma5
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plasma
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plasma*
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| Stored specimens: |
3 aliquots urine4
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4 aliquots citrated plasma 1 Vitamin C aliquot 4 urine aliquots
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| Stored specimens: |
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Platelets frozen from citrated plasma for mitochondrial DNA
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| Total specimens for storage in each examination: |
139,087
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94,238
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12,101
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12,000
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11,400
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1N includes 5% blind duplicates
2Aliquots = 13 aliquots 0.5 ml, 6 aliquots 1 ml.
3Aliquots = 8 aliquots 0.5 ml, 4 aliquots 1 ml.
4Aliquots = 2 ml, 1 acidified, 2 not.
5Aliquots = 0.5 ml
*plasma & platelets only collected from those who had cells collected in Year 3 (plasma sent to LCBR for pilot studies)
| Examination 1 | Examination 2 | Examination 3 | Examination 4 | Examination 5 | Examination 6 | Examination 7 | |
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| Analytes Obtained: |
Fasting glucose, insulin, two-hour (after glucola); glycated hemoglobin
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Fasting glucose TSH, Free T-4 (in those with TSH alert)
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Non-fasting, CBC Arterialized venous pH
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Fasting glucose, glycated hemoglobin
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Fasting glucose, glycated hemoglobin Total cholesterol, HDL-cholesterol, triglycerides
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| Analytes Obtained: |
Total cholesterol, HDL- and LDL- cholesterol, triglycerides, creatinine
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Total cholesterol
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| Analytes Obtained: |
Albumin, alkaline phosphatase
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| Analytes added: |
Serum IL-6, TNF-a, CRP, leptin, PAI-1, Oxidized LDL
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| Analytes proposed: |
Selected polymorphisms: ACE, IL-6, TNF-a, PPAR-8, RxR, HSP70-2, PAI-1 Selected musculoskeletal genes
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