Molecular Mechanisms of Circadian Clocks in Aging Tissues (R01)Funding Number: RFA-AG-13-007
Funding Type: RFA
Release Date: August 16, 2012
Expiration Date: November 8, 2012
Web Site: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-13-007.html
This FOA issued by the National Institute on Aging (NIA), National Institutes of Health (NIH), solicits grant applications from institutions/organizations that propose research to enhance the understanding of the molecular mechanisms that control circadian clocks in aging tissues.This FOA encourages studies on the roles of peripheral and extra suprachiasmatic nucleus (SCN) circadian clocks during aging.These studies include understanding the impact of alterations in the clock system on chromatin remodeling, gene expression, translation, signaling, and function of individual cells.In addition, studies are solicited on the pathophysiology of alterations to circadian clock regulation in aged tissues, with particular attention to the response of the clock system to metabolic/nutritional, environmental and pharmacological challenges.