The National Alzheimer's Coordinating Center was established by the National Institute on Aging (U01 AG016976) in 1999 to facilitate collaborative research and to record the cumulative enrollment of the NIA-funded Alzheimer’s Disease Centers (ADCs). Using data collected from these Centers across the United States, NACC has developed and maintains a large relational database of standardized clinical and neuropathological research data. In partnership with the Alzheimer's Disease Genetics Consortium (ADGC) and the National Cell Repository for Alzheimer's Disease (NCRAD), NACC provides a valuable resource for both exploratory and explanatory Alzheimer's disease research.
The NACC database, which is the largest resource of its kind in the U.S., serves as a cumulative record of the subjects enrolled at the ADCs since the beginning of the program in 1984. Between 1984 and 1999, when NACC was established, data on enrollees were collected mainly by retrospective data abstraction from existing records. With the creation of the Uniform Data Set in 2005, data were collected prospectively, using a standardized clinical evaluation administered at annual visits. The new data set provided NIA, the ADC Program, and researchers worldwide with comparability, detail, and power that had previously been unavailable, as well as the ability to track change over time on a wide variety of data elements.
The NACC database comprises the following data sets:
NACC data are freely available to all researchers, and NACC research scientists provide consulting at no charge to ensure the selection of appropriate data elements tailored to each research question. To submit a data request or for more information, please visit the NACC website.