Research and Funding

Interventions Testing Program (ITP)

Papers from the NIA Interventions Testing Program

Warner, H. R., Ingram, D., Miller, R. A., Nadon, N. L. and Richardson, A. G. (2000) Meeting Report: Program for testing biological interventions to promote healthy aging. Mechanisms of Aging and Development 115:199-208. PubMed http://www.ncbi.nlm.nih.gov/pubmed/10906513

Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Strong, R. (2007) NIA Interventions Testing Program: Study Design and an Interim Report. Aging Cell 6:565-575. PMID PMC2695675. PubMed http://www.ncbi.nlm.nih.gov/pubmed/17578509

Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M. and Harrison, D. E. (2008) Design of Aging Intervention Studies: the NIA Interventions Testing Program. AGE 30:187-199. [AGE online - http://dx.doi.org/10.1007/s11357-008-9048-1 ; NIHMSID47726] PubMed http://www.ncbi.nlm.nih.gov/pubmed/19424842

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Harrison, D. E. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7:641-650. PubMed http://www.ncbi.nlm.nih.gov/pubmed/18631321

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E. and Miller, R. A. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395. PubMed http://www.ncbi.nlm.nih.gov/pubmed/19587680

Miller, R. A., Harrison, D., Astle, C. M., Baur, J. A., deCabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., Pletcher, S., Sharp, Z. D., Sinclair, D., Starnes, J. W., Wilkinson, J. E., Nadon, N. L., Strong, R. (2011) Rapamycin, But Not Resveratrol or Simvastatin, Extends Lifespan of Genetically Heterogeneous Mice. J. Gerontology, Biological Sciences 66A:191-201. PubMed http://www.ncbi.nlm.nih.gov/pubmed/20974732.

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Carames, B., Friedline, S., Harrison, D., Lotz, M., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., and Miller, R. A. Rapamycin Slows Aging in Mice. (2012) Aging Cell 11:675-682. (PMID: 22587563)

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D., Teter, B., Williams, D., Zaveri, N., Nadon, N. L., Harrison, D. E. (2012) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium chain triglyceride oil on lifespan of genetically heterogeneous mice. J. Gerontology, Biological Sciences 68:6-16. (PMID 22451473)

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Carames, B., Friedline, S., Harrison, D., Lotz, M., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., and Miller, R. A.  Rapamycin Slows Aging in Mice.  (2012) Aging Cell 11:675-682.  (PMID: 22587563)

Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., Pletcher, S., Salmon, A. B., Sharp, Z. D., Van Roekel, S., Winkleman, L., Strong, R. Rapamycin-Mediated Lifespan Increase in Mice is Dose and Sex-Dependent and Metabolically Distinct from Dietary Restriction. (2013) Aging Cell doi: 10.1111/acel.12194.

Harrison D. E., Strong R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., Nelson, J. F., Simpkins, J. W., Smith, D., Wilkinson, J. E., and Miller, R. A.  Acarbose, 17-α-Estradiol, and Nordihydroguaiaretic Acid Extend Mouse Lifespan Preferentially in Males. (2013) Aging Cell, DOI: 10.1111/acel.12170.