Research and Funding

Interventions Testing Program (ITP)

Compounds In Testing

Each material is given in the diet at the following levels (part per million (PPM) by weight).

Cohort 1: C2004
Compound Concentration in food Age at treatment initiation
Aspirin
20 ppm
4 months
NFP
200 ppm
4 months
NDGA
2,500 ppm
9 months
4-OH-PBN
315 ppm
4 months

 

Cohort 2: C2005
Compound Concentration in food Age at treatment initiation
CAPE
30 ppm
4 months
CAPE
300 ppm
4 months
Enalapril Maleate
120 ppm
4 months
Rapamycin
14 ppm
20 month

 

Cohort 3: C2006
Compound Concentration in food Age at treatment initiation
Rapamycin
14 ppm
9 months
Simvastatin
12 ppm
10 months
Simvastatin
120 ppm
10 months
Resveratrol
300 ppm
12 months
Resveratrol
1200 ppm
12 months

 

Cohort 4: C2007
Compound Concentration in food Age at treatment initiation
Resveratrol
300 ppm
4 months
Oxaloacetic acid
2200 ppm
4 months
Green tea extract
2000 ppm
4 months
Curcumin
2000 ppm
4 months
Medium Chain Triglyceride Oil
60000 ppm
4 months

 

Cohort 5: C2009
Compound Concentration in food Age at treatment initiation
17α-Estradiol
4.8 ppm
10 months
Methylene Blue
28 ppm
4 months
Acarbose
1000 ppm
4 months
Rapamycin_LoPhase II
4.7 ppm
9 months
Rapamycin_MidPhase II
14 ppm
9 months
Rapamycin_HiPhase II
42 ppm
9 months

 

Cohort 6: C2010
Compound Concentration in food Age at treatment initiation
Fish Oil
15000 ppm
9 months
Fish Oil
50000 ppm
9 months
NDGA Lo_Phase II
800 ppm
6 months (M only)
NDGA Med_Phase II
2500 ppm
6 months (M only)
NDGA Hi_Phase II
5000 ppm
6 months (M & F)

 

Cohort 7: C2011
Compound Concentration in food Age at treatment initiation
Bile Acids
5000 ppm
5 months
Metformin
1000 ppm
9 months
Metformin + Rapamycin
1000 ppm M + 14 ppm R
9 months
Protandim®  *
600 ppm
10 months
17α-Estradiol
14.4 ppm
10 months

*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.

 

Cohort 8: C2012
Compound Concentration in food Age at treatment initiation
INT-767 FXR/TG5R agonist
180 ppm
10 months
Acarbose
1000 ppm
16 months
HBX (2-(2-hydroxyphenyl)-benzoxazole)
1 ppm
15 months
NDGA cross-section study: Males
2500 ppm
13 months
NDGA cross-section study: Females
5000 ppm
13 months

 

Cohort 9: C2013
Compound Concentration in food Age at treatment initiation
Ursolic Acid
2000 ppm
10 months
FXR agonist INT-747
60 ppm
9 months
Acarbose Phase II
2500 ppm
8 months
Acarbose Phase II
1000 ppm
8 months
Acarbose Phase II
400 ppm
8 months

 

Cohort 10: C2014
Compound Concentration in food Age at treatment initiation
Supplemental glycine
80,000 ppm
9 months
TM5441 – inhibitor of PAI-1
60 ppm
11 months
Inulin
600 ppm
11 months
Aspirin
60 ppm
11 months
Aspirin
200 ppm
11 months