This FOA solicits applications for a U24 Cooperative Agreement project to support a collaborative research infrastructure that includes a team of multidisciplinary scientists to plan translational research strategies to identify potential therapeutic targets based on findings of genetic factors influencing human lifespan and health span. In the context of this FOA, the term "target identification strategy" refers to a concerted set of applied research approaches to address a key step in the development of new therapeutic or preventive interventions, or repurposing existing interventions to delay onset of age-related conditions, including identification of molecules or pathways by which activities could be favorably modified.