The purpose of this Funding Opportunity Announcement (FOA) is to support the creation of a research resource infrastructure for the administration of research investigations using person-centered health outcomes, further referred to as the Person-Centered Outcomes Research Resource (PCORR). The overarching goal for the PCORR will be to facilitate person-centered outcome research by supporting the use and enhancements of the following four measurement information systems, currently funded as separate NIH programs: the the Patient Reported Outcomes Measurement Information System (PROMIS: http://www.nihpromis.org/ [1]); the NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox: http://www.nihtoolbox.org/ [2]); the Quality of Life (QOL); Outcomes in Neurological Disorders (Neuro-QOL: http://www.neuroqol.org/ [3]); and the Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me: http://www.air.org/files/4_pager_AIR_Health_Polict_2011_V10F.pdf [4]).