The purpose of this limited competition FOA is to allow the Dominantly Inherited Alzheimer's Network (DIAN) investigators to submit a continuation application. This is a unique multisite project studying early onset, autosomal dominant (familial) Alzheimer's Disease. By understanding this relatively rare, inherited form of the disorder, we will gain important insights into the much more common, non-familial, late-onset Alzheimer's. This FOA solicits a renewal application for another 5-year cycle of DIAN, and to allow resubmission and/or revision applications in subsequent years. Revision applications may not request support beyond the project end date of the Parent U19 award.