The NIA is committed to identifying effective treatments for diseases and conditions associated with aging, including disorders of neural systems and to ascertain the associated health outcomes by supporting robust, well-planned and designed, and well-executed clinical trials. This funding opportunity announcement (FOA) aims to support the planning activities needed for the successful execution of complex and multi-site clinical trials as well as the establishment of Protocol and Manual of Procedures (MOP) as recommended by the NIA Clinical Research Study Investigator's Toolbox (http://www.nia.nih.gov/research/dgcg/clinical-research-study-investigato... [1]).