This Notice announces a new Special Council Review (SCR) policy to help NIH effectively manage resources. The policy will require NIH Institute and Center (IC) Advisory Councils to perform additional review of grant and cooperative agreement applications from Program Director(s)/Principal Investigator(s) [PD(s)/PI(s)] who receive $1.0 million per year in direct costs from active NIH awards. This policy does not represent a cap on NIH funding.