The National Institute on Aging (NIA) invites applications for cooperative agreements (U01s) from investigators or groups of investigators (e.g., multiple PD(s)/PI(s) capable of, and interested in, participating in a Caenorhabditis Intervention Testing Program (CITP). The goal is to identify pharmacological interventions that increase lifespan and/or healthspan in a robust manner when tested using multiple species of the simple invertebrate Caenorhabditis and/or multiple strains of Caenorhabditis elegans. Human populations are genetically heterogeneous and thus, in order to work in humans, any intervention that extends lifespan/healthspan needs to do so within a variety of genetic backgrounds. Testing of promising compounds in a variety of genetic backgrounds within a species with a short, well-studied lifespan and healthspan, should accelerate the current rate of discovery.