The goal of this interagency funding opportunity announcement (FOA) is to support the development of multiscale models to accelerate biological, biomedical, behavioral, environmental and clinical research. The NIH, DOE, FDA, and NSF recognize that to efficiently and effectively address the challenges of understanding multiscale biological and behavioral systems, researchers will need predictive, computational models that encompass multiple biological and behavioral scales. This FOA also encourages the development of new, non-standard modeling methods and experimental approaches to facilitate multiscale modeling.