The purpose of this FOA is to support the development of human induced pluripotent stem (iPS) cells and other reprogrammed cells for aging and Alzheimers disease modeling. The molecular and functional characterization of aged or Alzheimers disease phenotypes in specific cell types derived from human iPS and other reprogrammed cells is expected to provide proof-of-concept evidence that human reprogrammed cells can be valid cell models of aging and Alzheimers disease.