The Health and Retirement Study (HRS; see at http://hrsonline.isr.umich.edu/ [1] ) is a longitudinal, nationally representative sample of the US population aged 50 years and older (plus spouses) with an oversample of African and Hispanic Americans and a total sample size of over 20,000). Using funds from the American Reinvestment and Recovery Act, the HRS is currently conducting genome-wide scans of DNA samples from approximately 20,000 participants, using the Illumina HumanOmni 2.5 Quad chip. It is anticipated that the genotype data for the first 13,000 subjects will be released to the public via dbGaP in the Fall of 2011, with data from the remaining participants to be released by the end of 2012. This FOA encourages applications taking advantage of the newly available genetic data to advance our understanding of how genetic, behavioral, and psychosocial factors affect the health and well-being of older Americans.