No
Offices:
DAB [1]
Each material is given in the diet at the following levels (part per million (PPM) by weight).
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| Aspirin | 20 ppm | 4 months |
| NFP | 200 ppm | 4 months |
| NDGA | 2,500 ppm | 9 months |
| 4-OH-PBN | 315 ppm | 4 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| CAPE | 30 ppm | 4 months |
| CAPE | 300 ppm | 4 months |
| Enalapril Maleate | 120 ppm | 4 months |
| Rapamycin | 14 ppm | 20 month |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| Rapamycin | 14 ppm | 9 months |
| Simvastatin | 12 ppm | 10 months |
| Simvastatin | 120 ppm | 10 months |
| Resveratrol | 300 ppm | 12 months |
| Resveratrol | 1200 ppm | 12 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| Resveratrol | 300 ppm | 4 months |
| Oxaloacetic acid | 2200 ppm | 4 months |
| Green tea extract | 2000 ppm | 4 months |
| Curcumin | 2000 ppm | 4 months |
| Medium Chain Triglyceride Oil | 60000 ppm | 4 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| 17α-Estradiol | 4.8 ppm | 10 months |
| Methylene Blue | 28 ppm | 4 months |
| Acarbose | 1000 ppm | 4 months |
| Rapamycin_LoPhase II | 4.7 ppm | 9 months |
| Rapamycin_MidPhase II | 14 ppm | 9 months |
| Rapamycin_HiPhase II | 42 ppm | 9 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| Fish Oil | 15000 ppm | 9 months |
| Fish Oil | 50000 ppm | 9 months |
| NDGA Lo_Phase II | 800 ppm | 6 months (M only) |
| NDGA Med_Phase II | 2500 ppm | 6 months (M only) |
| NDGA Hi_Phase II | 5000 ppm | 6 months (M & F) |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| Bile Acids | 5000 ppm | 5 months |
| Metformin | 1000 ppm | 9 months |
| Metformin + Rapamycin | 1000 ppm M + 14 ppm R | 9 months |
| Protandim® * | 600 ppm | 10 months |
| 17α-Estradiol | 14.4 ppm | 10 months |
*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
| INT-767 FXR/TG5R agonist | 180 ppm | 10 months |
| Acarbose | 1000 ppm | 16 months |
| HBX (2-(2-hydroxyphenyl)-benzoxazole) | 1 ppm | 15 months |
| NDGA cross-section study | 2500 ppm for Males
5000 ppm for Females |
13 months |