Each material is given in the diet at the following levels (part per million (PPM) by weight).
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Aspirin |
20 ppm |
4 months |
|
NFP |
200 ppm |
4 months |
|
NDGA |
2,500 ppm |
9 months |
|
4-OH-PBN |
315 ppm |
4 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
CAPE |
30 ppm |
4 months |
|
CAPE |
300 ppm |
4 months |
|
Enalapril Maleate |
120 ppm |
4 months |
|
Rapamycin |
14 ppm |
20 month |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Rapamycin |
14 ppm |
9 months |
|
Simvastatin |
12 ppm |
10 months |
|
Simvastatin |
120 ppm |
10 months |
|
Resveratrol |
300 ppm |
12 months |
|
Resveratrol |
1200 ppm |
12 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Resveratrol |
300 ppm |
4 months |
|
Oxaloacetic acid |
2200 ppm |
4 months |
|
Green tea extract |
2000 ppm |
4 months |
|
Curcumin |
2000 ppm |
4 months |
|
Medium Chain Triglyceride Oil |
60000 ppm |
4 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
17α-Estradiol |
4.8 ppm |
10 months |
|
Methylene Blue |
28 ppm |
4 months |
|
Acarbose |
1000 ppm |
4 months |
|
Rapamycin_LoPhase II |
4.7 ppm |
9 months |
|
Rapamycin_MidPhase II |
14 ppm |
9 months |
|
Rapamycin_HiPhase II |
42 ppm |
9 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Fish Oil |
15000 ppm |
9 months |
|
Fish Oil |
50000 ppm |
9 months |
|
NDGA Lo_Phase II |
800 ppm |
6 months (M only) |
|
NDGA Med_Phase II |
2500 ppm |
6 months (M only) |
|
NDGA Hi_Phase II |
5000 ppm |
6 months (M & F) |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Bile Acids |
5000 ppm |
5 months |
|
Metformin |
1000 ppm |
9 months |
|
Metformin + Rapamycin |
1000 ppm M + 14 ppm R |
9 months |
|
Protandim® * |
600 ppm |
10 months |
|
17α-Estradiol |
14.4 ppm |
10 months |
*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.